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Changes in synaptic transmission, calcium current, and neurite growth by perfluorinated compounds are dependent on the chain length and functional group
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Yantai Institute of Coastal Zone Research for Sustainable Development, Chinese Academy of Sciences, Yantai, Shandong 264003, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China .ORCID iD: 0000-0002-5729-1908
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China .
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2009 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 43, no 6, 2099-2104 p.Article in journal (Refereed) Published
Abstract [en]

Scientific and public concerns on perfluorinated compounds (PFCs) are increasingly growing because of their environmental persistency, bioaccumulation, and extensive distribution throughout the world. Little is known about the effects of PFCs on neural function and the underlying mechanisms. Recent evidence suggests that the toxicological effects of PFCs are closely correlated with their carbon chain lengths. In this present work, the actions of PFCs with varying chain length on cultured rat hippocampal neurons and possible action patterns were examined. Increases in the frequencies of spontaneous miniature postsynaptic current (mPSC) were commonly found in cultured neurons when perfused with PFCs. The increase of mPSC frequency was in proportion to the carbon chain length, and the potency of perfluorinated carboxylates was less pronounced than that of perfluorinated sulfonates. A comparable but less perceptible trend was also found for the amplitudes of voltage-dependent calcium current (ICa). No regular change in pattern was observed for the effects of PFCs on activation and inactivation kinetics of ICa. Furthermore, prolonged treatment of PFCs inhibited the neurite growth of neuronsto various degrees. Comparisons between nonfluorinated and perfluorinated analogues demonstrated thatthefluorination in alkyl chain exerts stronger actions on neurons as compared to the surfactant activity. This study shows that PFCs exhibit adverse effects on cultured neurons to various extents, which is dependent on the carbon chain length and functional group attached to the fully fluorinated alkyl chain.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2009. Vol. 43, no 6, 2099-2104 p.
Keyword [en]
Action Potentials; Animals; Calcium; Environmental Pollutants; Hydrocarbons, Fluorinated; Neurites; Rats; Rats, Sprague-Dawley; Synaptic Transmission
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-38465DOI: 10.1021/es802985eISI: 000264108800071PubMedID: 19368220Scopus ID: 2-s2.0-64549155569OAI: oai:DiVA.org:oru-38465DiVA: diva2:764968
Note

Sponsors:

National Basic Research Program of China Grant(s): 2009CB421600 

National Natural Science Foundation of China Grant(s): 20897010  20621703 

Available from: 2014-11-21 Created: 2014-11-07 Last updated: 2017-10-17Bibliographically approved

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