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Impact of silver nanoparticles on human cells: effect of particle size
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
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2010 (English)In: Nanotoxicology, ISSN 1743-5390, Vol. 4, no 3, 319-330 p.Article in journal (Refereed) Published
Abstract [en]

This work investigated the cytotoxicities of three silver nanoparticles (SNPs) SNP-5, SNP-20 and SNP-50 with different sizes ( approximately 5 nm, approximately 20 nm and approximately 50 nm) using four human cell models (A549, SGC-7901, HepG2 and MCF-7). Endpoints included cell morphology, cell viability, cellular membrane integrity, oxidative stress and cell cycle progression. Observable deleterious effects on the cell morphologies and membrane integrity were induced by SNP-5 and SNP-20. SNPs elevated the ROS levels in cells and arrested the cells at S phase. Apoptosis occurred for 4-9% of the exposed cells. All these cellular responses as well as EC50 values were found to be size-dependent for the tested SNPs. Ultrastructural observations confirmed the presence of SNPs inside cells. Elemental analysis of silver in cells by ICP-MS showed that smaller nanoparticles enter cells more easily than larger ones, which may be the cause of higher toxic effects. The findings may assist in the design of SNP applications and provide insights into their toxicity.

Place, publisher, year, edition, pages
New York: Informa Healthcare, 2010. Vol. 4, no 3, 319-330 p.
Keyword [en]
Cytotoxicity; Silver nanoparticles; Size-dependent
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-38451DOI: 10.3109/17435390.2010.483745ISI: 000283555100006PubMedID: 20795913Scopus ID: 2-s2.0-77955905880OAI: oai:DiVA.org:oru-38451DiVA: diva2:764982
Note

Funding Agencies:

National Natural Science Foundation of China 20537020

Chinese Academy of Sciences KZCXZ-YW-420-21

Key Project in the National Science & Technology Pillar Program 2007BAC27B02-1a

Available from: 2014-11-21 Created: 2014-11-07 Last updated: 2017-10-17Bibliographically approved

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