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The in vitro estrogenic activities of polyfluorinated iodine alkanes
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, People’s Republic of China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, People’s Republic of China.ORCID iD: 0000-0002-5729-1908
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, People’s Republic of China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, People’s Republic of China.
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2012 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 120, no 1, p. 119-125Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Polyfluorinated iodine alkanes (PFIs) are important intermediates in the synthesis of organic fluoride products. Recently, PFIs have been detected in fluoropolymers as residual raw materials, as well as in the ambient environment.

OBJECTIVES: High production volumes and potential environmental releases of PFIs might become a concern, but the exposure risk and toxicity of these chemicals are still unclear. In this study, we investigated the potential estrogenic effects of PFIs.

METHODS: We studied the estrogenic effects of fluorinated iodine alkanes (FIAs), fluorinated telomer iodides (FTIs), and fluorinated diiodine alkanes (FDIAs) using the E-screen and MVLN assays and the evaluation of estrogen-responsive genes in MCF-7 cells.

RESULTS: FIAs have an iodine atom at one end of the perfluorinated carbon chain. 1-Iodoperfluorohexane (PFHxI) and 1-iodoperfluorooctane (PFOI) promoted the proliferation of MCF-7 cells, induced luciferase activity in MVLN cells, and up-regulated the expression of TFF1 and EGR3. In these assays, other FIAs gave negative responses. FDIAs have an iodine atom at each end of the perfluorinated carbon chain, and all the FDIAs showed estrogenic effects. The estrogenic potencies of FIAs and FDIAs correlate well with the carbon chain length of the chemicals. The optimum chain length for estrogenic effects is six carbons, and then eight and four carbons. All FTIs have a single iodine atom at the end of a partially fluorinated carbon chain. None of the FTIs showed estrogenic effects in the tests.

CONCLUSIONS: The estrogenic effects of PFIs are dependent on the structural features of iodine substitution and chain length. This research will be helpful in further understanding the estrogenic effects of perfluorinated compounds.

Place, publisher, year, edition, pages
USA: National Institute of Environmental Health Sciences (NIEHS) , 2012. Vol. 120, no 1, p. 119-125
Keywords [en]
endocrine disruptor, estrogenic effects, in vitro assay, perfluorinated chemicals, polyfluorinated iodine alkanes
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-38440DOI: 10.1289/ehp.1103773ISI: 000299650400035PubMedID: 21990342OAI: oai:DiVA.org:oru-38440DiVA, id: diva2:764994
Note

Sponsors:

Ministry of Science and Technology of the People's Republic of China Grant(s): 2007BAC27B02-1a  2009AA06Z407 

National Natural Science Foundation of China Grant(s): B20977100  20921063  20897011 

Available from: 2014-11-21 Created: 2014-11-07 Last updated: 2017-12-05Bibliographically approved

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Wang, Thanh

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