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Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river
University of Heidelberg, Heidelberg, Germany. (MTM)ORCID iD: 0000-0002-2356-6686
University of Heidelberg, Heidelberg, Germany.
Örebro University, Department of Natural Sciences. (MTM)ORCID iD: 0000-0001-6217-8857
Örebro University, Department of Natural Sciences. (MTM)ORCID iD: 0000-0003-4128-8226
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2008 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 390, no 8, p. 2009-2019Article in journal (Refereed) Published
Abstract [en]

This study is a consequence of a distinct fishdecline in the Danube river since the beginning of the 1990s. In contrast to the decline of fish population, former studies have repeatedly documented that the water quality along the Danube river is improving. However, the conclusion of a pilot study in 2002 was that a high hazard potentialis associated with local sediments. The present study documents that sediment samples from the Danube river showed comparatively high aryl hydrocarbon receptor mediated activity in biotests, using the cell lines GPC.2D.Luc, H4IIE(DR-CALUX®) and RTL-W1. The combination of chemical analysis, fractionation techniques and different in vitro tests revealed that priority pollutants could not explain the main induction, even though the concentrations of prioritypolycyclic aromatic hydrocarbons (PAHs) were very high (maximum in the tributary Schwarzach, sum of 16 EPAPAHs 26 μg/g). In conclusion, this investigation shows that nonpriority pollutants mainly mediate the high inductionrates. Nevertheless, owing to the effects of PAHs towards fish and the connection between dioxin-like activity andcarcinogenicity, the link between contamination and the fish population decline cannot be ruled out.

Place, publisher, year, edition, pages
Springer, 2008. Vol. 390, no 8, p. 2009-2019
National Category
Environmental Sciences
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URN: urn:nbn:se:oru:diva-39651DOI: 10.1007/s00216-007-1652-xISI: 000254755700006Scopus ID: 2-s2.0-43349100198OAI: oai:DiVA.org:oru-39651DiVA, id: diva2:771492
Available from: 2014-12-14 Created: 2014-12-14 Last updated: 2017-12-05Bibliographically approved

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Keiter, Steffenvan Bavel, BertHagberg, JessikaEngwall, MagnusOlsman, Helena

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