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DanTox-a novel joint research project using zebrafish (Danio rerio) to identify specific toxicity and molecular modes of action of sediment-bound pollutants
Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany. (MTM)ORCID iD: 0000-0002-2356-6686
Institute for Environmental Research (Biology V), Department of Ecosystem Analysis, RWTH Aachen University, Aachen, Germany.
German Federal Institute for Hydrology (BfG), Koblenz, Germany.
Aquatic Ecology and Toxicology Group, Department of Zoology, University of Heidelberg, Heidelberg, Germany.
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2010 (English)In: Journal of Soils and Sediments, ISSN 1439-0108, E-ISSN 1614-7480, Vol. 10, no 4, p. 714-717Article in journal (Refereed) Published
Abstract [en]

Introduction: The European Water Framework Directive aimsto achieve a good ecological and chemical status in surface water of European rivers by the year 2015. Since sediments and particulate matter act as secondary sources for pollutants, applied sediment toxicology is perceived to play a major rolefor obtaining new knowledge that can contribute to successful attainment of the goal. However, the existing bioassays for sediment toxicity analyses do not provide sufficient data concerning bioavailability of environmental pollutants. In this regard, there is an urgent need to combine sediment contact assays with gene expression analysis to investigate mechanism-specific sediment toxicity.

Purpose: The aim of the novel joint research project is todevelop a eukaryotic test system, which can be used to investigate the ecotoxicological effects of contaminated sediments on gene expression level (DNA-array and RT-PCR).Current ecotoxicological research customarily involves a battery of bioassays to cover different toxicological endpoints (e.g., teratogenicity, genotoxicity, mutagenicity, Ah-receptor mediated toxicity, neurotoxicity). In contrast, methods that detect alterations in gene expression offer deeper insight by elucidating how chemical exposure and/or environmental challenge affect multiple metabolic pathways leading to these particular kinds of toxic response. Gene expression profiles reflect the way cells and organisms adapt or respond to a changing environment.

Conclusion: The present project aspires to increase the fundamental molecular and physiological knowledge concerning the mode of action of environmental toxicants in zebrafish (Danio rerio). By working with partners from the academic and research institutions as well as from industry and waterway regulations, the success of this basic research-driven joint project in terms of development and implementation of novel sediment toxicity methods will be realized.

Place, publisher, year, edition, pages
Heidelberg, Germany: Springer, 2010. Vol. 10, no 4, p. 714-717
Keywords [en]
Danio rerio, Genomics, Sediments, Toxicity
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-39948DOI: 10.1007/s11368-010-0221-7ISI: 000277555800011Scopus ID: 2-s2.0-77956432881OAI: oai:DiVA.org:oru-39948DiVA, id: diva2:774003
Available from: 2014-12-20 Created: 2014-12-20 Last updated: 2018-09-06Bibliographically approved

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Keiter, Steffen

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