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Quantitative assessment of the embryotoxic potential of NSO-heterocyclic compounds using zebrafish (Danio rerio)
Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Aachen, Germany.
Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Aachen, Germany.
Department of Ecosystem Analysis, Institute for Environmental Research, RWTH Aachen University, Aachen, Germany.
Department of Environmental Biotechnology, Water Technology Center (TZW), Karlsruhe, Germany.
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2012 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 33, p. 224-232Article in journal (Refereed) Published
Abstract [en]

Heterocyclic aromatic compounds (NSO-HET) have frequently been detected in the environment. Several studies have concluded that NSO-HET pose a threat to organisms in waters, sediments and soils. However, few publications are available assessing the ecotoxicology of NSO-HET. The present study aims toassess the embryo toxicity of heterocycles using Danio rerio. A combination of the Fish Embryo Toxicity Test and analytical quantification should aid to determine the hazard potential. Changes of the total concentrations due to sorption or volatility were quantified by GC/MS. Loss of compounds during the testwas observed primarily for volatile or hydrophobic NSO-HET. The LC50 calculated with nominal concentrations underestimates the toxicity by a factor up to 16 (2 h), demonstrating that a chemical analysis for comparing nominal and measured concentrations is essential for such investigations.

Place, publisher, year, edition, pages
Oxford, United Kingdom: Springer, 2012. Vol. 33, p. 224-232
Keywords [en]
Heterocyclic aromatic compounds, NSO-HET, Zebrafish, Embryo toxicity, Fish embryo toxicity test
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-39953DOI: 10.1016/j.reprotox.2011.12.005ISI: 000302204700012PubMedID: 22244949Scopus ID: 2-s2.0-84858439206OAI: oai:DiVA.org:oru-39953DiVA, id: diva2:774054
Note

Note: Deutscher Verein des Gas- und Wasserfaches Technologiezentrum Wasser (DVGW-TZW)

Available from: 2014-12-21 Created: 2014-12-21 Last updated: 2018-05-14Bibliographically approved

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Keiter, Steffen

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