oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Prognostic significance of YWHAZ expression in localized prostate cancer
Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany.
Inst Pathol, Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany.
Örebro University Hospital. Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Laboratory Medicine, University Hospital of Örebro, Örebro, Sweden; Department of Urology, University Hospital of Örebro, Örebro, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Urology, University Hospital of Örebro, Örebro, Sweden.ORCID iD: 0000-0001-5533-7899
Show others and affiliations
2014 (English)In: Prostate Cancer and Prostatic Diseases, ISSN 1365-7852, E-ISSN 1476-5608, Vol. 17, no 4, p. 310-314Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Prostate cancer (PCa) patients are often over-treated because of the lack of biomarkers needed to distinguish the lethal from the indolent form of PCa. YWHAZ was recently identified as a potential therapeutic target in castration-resistant PCa (CRPC). Therefore, this study focused on determining the prognostic significance of YWHAZ in localized PCa.

METHODS: YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy. Kaplan-Meier analysis and Cox proportional-hazards models were, used to assess the prognostic value of YWHAZ intensity.

RESULTS: High YWHAZ expression was strongly associated with high Gleason score at the time of diagnosis (P<0.001) and PSA relapse (P=0.001). Importantly, patients with high expression of YWHAZ had a higher risk of CRPC development (P=0.002) and reduced survival time (P=0.002).

CONCLUSIONS: Our findings indicate that YWHAZ could serve as a promising prognostic biomarker in localized PCa to predict poor prognosis and to identify a subgroup of tumors, which might benefit from earlier adjuvant or YWHAZ-targeted therapy.

Place, publisher, year, edition, pages
Nature Publishing Group, 2014. Vol. 17, no 4, p. 310-314
National Category
Cancer and Oncology Urology and Nephrology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-40164DOI: 10.1038/pcan.2014.32ISI: 000344835400002PubMedID: 25156059Scopus ID: 2-s2.0-84908887461OAI: oai:DiVA.org:oru-40164DiVA, id: diva2:776487
Note

Funding Agencies:

Wilhelm Sander Foundation 2011.077.1

Rudolf-Becker-Foundation

German Research Foundation (Deutsche Forschungsgemeinschaft (DFG), Emmy-Noether-Program) PE1179/2-1

Medical Faculty of the University of Bonn (BONFOR)

Note: ToPCaP is a multinational research institute w. research locations in seven western countries

Available from: 2015-01-07 Created: 2015-01-07 Last updated: 2018-06-14Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Carlsson, JessicaAndrén, Ove

Search in DiVA

By author/editor
Svensson, Maria A.Carlsson, JessicaAndrén, Ove
By organisation
Örebro University HospitalSchool of Health and Medical Sciences, Örebro University, Sweden
In the same journal
Prostate Cancer and Prostatic Diseases
Cancer and OncologyUrology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 168 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf