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Microdialysis methods for measuring human metabolism
Centre for Surgical Sciences, Karolinska Institutet, Stockholm; Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Huddinge.
Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm.
Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm.
Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm.ORCID iD: 0000-0003-2636-4745
2004 (English)In: Current opinion in clinical nutrition and metabolic care, ISSN 1363-1950, E-ISSN 1473-6519, Vol. 7, no 5, 515-21 p.Article in journal (Refereed) Published
Abstract [en]

Purpose of review: To discuss the advantages and limitations of the microdialysis technique as a diagnostic and research tool using recent findings on human metabolism.

Recent findings: Results from several studies have supported the potential of microdialysis as a diagnostic tool for metabolic monitoring in difficult accessible tissues (brain, liver, intestine). However, despite promising results, no clear diagnostic measures have yet emerged. Several studies combining microdialysis with stable isotope tracers have shown that this approach has great potential for studying human metabolism non-invasively in specific tissue beds in a more dynamic way.

Summary: Bearing in mind the limitations and assumptions, the microdialysis technique is a useful tool in investigations of human metabolism. Its main advantages are that it can be used safely with low-grade invasiveness in humans, and thereby allows continuous sampling over prolonged periods of time from specific tissues without taking any biopsies. At present, microdialysis would seem to be useful as a diagnostic tool when integrated in the total clinical, physiological and pharmacological evaluation. Within human metabolic research, microdialysis has been and will be a very useful technique.

Place, publisher, year, edition, pages
Philadelphia, USA: Lippincott Williams & Wilkins, 2004. Vol. 7, no 5, 515-21 p.
Keyword [en]
human, metabolism, microdialysis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-40383DOI: 10.1097/00075197-200409000-00003ISI: 000223521600002PubMedID: 15295271Scopus ID: 2-s2.0-13444295122OAI: oai:DiVA.org:oru-40383DiVA: diva2:777152
Available from: 2015-01-08 Created: 2015-01-08 Last updated: 2016-05-27Bibliographically approved

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