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Prognostic significance of Cyclin A in epidermoid anal cancer
Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm; Department for Clinical Science Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm.
Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm.
Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm.
Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm.
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2006 (English)In: Oncology Reports, ISSN 1021-335X, Vol. 16, no 3, 443-9 p.Article in journal (Refereed) Published
Abstract [en]

Ultimately aiming at a more individualized therapeutic approach in epidermoid anal cancer, this study explored the prognostic and predictive impact of a set of tumour markers. From a population-based cohort of 276 patients with epidermoid anal cancer, treated according to prospective protocols, 215 pre-treatment biopsies were investigated using immunohistochemistry. The expression of p53, p21, Cyclin A and CD31 was measured semi-quantitatively. The expression rate was classified as high when immunostaining was seen in > 5% of the tumour cells for p53 and p21, > 20% in Cyclin A and, above median vessel count for CD31. Marker expression was correlated to survival and treatment response. A high Cyclin A expression correlated significantly with improved overall (77% vs 59%, p = 0.005) and tumour-specific (81% vs 64%, p = 0.009) survival at 5 years. Also, the locoregional failure rate was significantly lower in patients with a high Cyclin A expression (12% vs 24%, p < 0.05). In a multivariate Cox analysis Cyclin A was an independent prognostic factor. A low p21 expression correlated with a reduced rate of locoregional failure (14% vs 27%, p < 0.05) but no impact on survival was found. For p53 and CD31 no significant correlations were obtained. Cyclin A may be an indicator of radiosensitivity and a valuable prognostic marker in epidermoid anal cancer.

Place, publisher, year, edition, pages
Athens, Greece: Professor D A Spandidos , 2006. Vol. 16, no 3, 443-9 p.
Keyword [en]
Anus neoplasm, prognosis, Cyclin A, radiotherapy, p53, p21
National Category
Medical and Health Sciences Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-40366ISI: 000239733300001PubMedID: 16865241Scopus ID: 2-s2.0-33749170155OAI: oai:DiVA.org:oru-40366DiVA: diva2:777192
Available from: 2015-01-08 Created: 2015-01-08 Last updated: 2016-05-27Bibliographically approved

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