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The history of genetics in inflammatory bowel disease
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.ORCID iD: 0000-0003-0122-7234
2014 (English)In: Annals of Gastroenterology, ISSN 1108-7471, E-ISSN 1792-7463, Vol. 27, no 4, p. 294-303Article, review/survey (Refereed) Published
Abstract [en]

The influence of genetics in the etiology of inflammatory bowel disease (IBD) was initially demonstrated by epidemiological data, including differences in prevalence among different ethnic groups, familial aggregation of IBD, concordance in twins, and association with genetic syndromes. These early observations paved the way to molecular genetics in IBD, and culminated in the identification of nucleotide-binding oligomerization domain containing 2 (NOD2) gene as an IBD risk gene in 2001. As in other complex diseases, the advent of Genome Wide Association studies has dramatically improved the resolution of the IBD genome and our understanding of the pathogenesis of IBD. However, the complexity of the genetic puzzle in IBD seems more pronounced today than ever previously. In total, 163 risk genes/loci have been identified, and the corresponding number of possible causal variants is challenging. The great majority of these loci are associated with both Crohn's disease and ulcerative colitis, suggesting that nearly all of the biological mechanisms involved in one disease play some role in the other. Interestingly, a large proportion of the IBD risk loci are also shared with other immune-mediated diseases, primary immunodeficiencies and mycobacterial diseases.

Place, publisher, year, edition, pages
Athens, Greece: Hellenic Society of Gastroenterology , 2014. Vol. 27, no 4, p. 294-303
Keywords [en]
Inflammatory bowel disease, genetics, genetic epidemiology
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-41215PubMedID: 25331623Scopus ID: 2-s2.0-84922378529OAI: oai:DiVA.org:oru-41215DiVA, id: diva2:779946
Available from: 2015-01-13 Created: 2015-01-13 Last updated: 2017-12-05Bibliographically approved

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Halfvarson, Jonas

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