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Incorporation of Mycobacterium tuberculosis lipoarabinomannan into macrophage membrane rafts is a prerequisite for the phagosomal maturation block
Linköping University, Linköping.
Linköping University, Linköping.
Linköping University, Linköping.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Linköping University, Linköping.ORCID iD: 0000-0002-4319-7208
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2008 (English)In: Infection and Immunity, ISSN 0019-9567, E-ISSN 1098-5522, Vol. 76, no 7, p. 2882-7Article in journal (Refereed) Published
Abstract [en]

Lipoarabinomannan (LAM) is one of the key virulence factors for Mycobacterium tuberculosis, the etiological agent of tuberculosis. During uptake of mycobacteria, LAM interacts with the cell membrane of the host macrophage and can be detected throughout the cell upon infection. LAM can inhibit phagosomal maturation as well as induce a proinflammatory response in bystander cells. The aim of this study was to investigate how LAM exerts its action on human macrophages. We show that LAM is incorporated into membrane rafts of the macrophage cell membrane via its glycosylphosphatidylinositol anchor and that incorporation of mannose-capped LAM from M. tuberculosis results in reduced phagosomal maturation. This is dependent on successful insertion of the glycosylphosphatidylinositol anchor. LAM does not, however, induce the phagosomal maturation block through activation of p38 mitogen-activated protein kinase, contradicting some previous suggestions.

Place, publisher, year, edition, pages
Washington DC, USA: American society for microbiology , 2008. Vol. 76, no 7, p. 2882-7
National Category
Medical and Health Sciences Immunology in the medical area
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URN: urn:nbn:se:oru:diva-41300DOI: 10.1128/IAI.01549-07ISI: 000257172300008PubMedID: 18426888Scopus ID: 2-s2.0-46449133631OAI: oai:DiVA.org:oru-41300DiVA, id: diva2:780272
Available from: 2015-01-14 Created: 2015-01-14 Last updated: 2018-01-11Bibliographically approved

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Särndahl, Eva

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