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Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization
Division of Organic Chemistry, Department of Physics, Biology and Chemistry (IFM), Linköping University, Linköping; Integrative Regenerative Medicine Center (IGEN), Linköping University, Linköping.
Division of Organic Chemistry, Department of Physics, Biology and Chemistry (IFM), Linköping University, Linköping; Division of Cell Biology, Department of Clinical and Experimental Medicine (IKE), Linköping University, Linköping; Integrative Regenerative Medicine Center (IGEN), Linköping University, Linköping.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Integrative Regenerative Medicine Center (IGEN), Linköping University, Linköping. (Cardiovascular Research Center)
Division of Molecular Physics, Department of Physics, Biology and Chemistry (IFM), Linköping University, Linköping; Division of Cell Biology, Department of Clinical and Experimental Medicine (IKE), Linköping University, Linköping; Integrative Regenerative Medicine Center (IGEN), Linköping University, Linköping.
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2014 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 15, no 7, 2359-2368 p.Article in journal (Refereed) Published
Abstract [en]

The sulfated marine polysaccharide fucoidan has been reported to have health benefits ranging from antivirus and anticancer properties to modulation of high blood pressure. Hence, they could enhance the biological function of materials for biomedical applications. However, the incorporation of fucoidan into biomaterials has been difficult, possibly due to its complex structure and lack of suitable functional groups for covalent anchoring to biomaterials. We have developed an approach for a rapid synthesis of fucoidanmimetic glycopolymer chains through cyanoxyl-mediated freeradical polymerization, a method suitable for chain-end functionalizing and subsequent linkage to biomaterials. The resulting sulfated and nonsulfated methacrylamido α-L-fucoside glycopolymers’ fucoidan-mimetic properties were studied in HSV-1 infection and platelet activation assays. The sulfated glycopolymer showed similar properties to natural fucoidan in inducing platelet activation and inhibiting HSV-1 binding and entry to cells, thus indicating successful syntheses of fucoidan-mimetic glycopolymers.

Place, publisher, year, edition, pages
Washington, USA: American Chemical Society (ACS), 2014. Vol. 15, no 7, 2359-2368 p.
National Category
Medical and Health Sciences Biochemistry and Molecular Biology
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-41343DOI: 10.1021/bm5002312ISI: 000339090500003PubMedID: 24813544Scopus ID: 2-s2.0-84904312236OAI: oai:DiVA.org:oru-41343DiVA: diva2:780368
Funder
EU, European Research CouncilSwedish Research Council
Available from: 2015-01-14 Created: 2015-01-14 Last updated: 2016-09-28Bibliographically approved

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Grenegård, Magnus
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