oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Expression of retinoic acid target genes in coronary artery disease
University of Oslo, Oslo, Norway.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
University of Oslo, Oslo, Norway.
University of Oslo, Oslo, Norway.
Show others and affiliations
2014 (English)In: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 33, no 3, p. 677-86Article in journal (Refereed) Published
Abstract [en]

Coronary atherosclerosis can lead to myocardial infarction, and secondarily to post-infarct remodelling and heart failure. Retinoic acid (RA) influences cell proliferation. We hypothesized that RA could influence gene expression and proliferation of cardiovascular cells. Left ventricular biopsies from patients with end-stage heart failure due to coronary artery disease (CAD) or dilated cardiomyopathy were investigated for the content of RA metabolites using liquid chromatography mass spectrometry (LC-MS/MS), and compared with healthy donors. All-trans retinoic acid (ATRA) was increased in the hearts of CAD patients. Gene expression (quantitative PCR) of RA target genes was not influenced in failing hearts, but was increased in the hearts of patients with CAD undergoing open heart surgery. The expression of RA target genes was increased in atherosclerotic lesions from carotid arteries compared to healthy arteries. Stimulation of cardiomyocytes, cardiofibroblasts, smooth muscle cells and endothelial cells with ATRA increased the gene expression of the key enzymes. Cardiofibroblast and smooth muscle cell proliferation were reduced by ATRA, which increased endothelial cell proliferation. Coronary artery disease leads to increased expression of RA target genes. ATRA accumulated in the failing human heart. All investigated cell types present in the heart had induced expression of RA target genes when stimulated with ATRA, which also influenced cell proliferation.

Place, publisher, year, edition, pages
Athens, Greece: Spandidos Publications , 2014. Vol. 33, no 3, p. 677-86
Keywords [en]
gene expression, all-trans retinoic acid, heart failure, atherosclerosis
National Category
Cell and Molecular Biology
Research subject
Medicine; Medicine
Identifiers
URN: urn:nbn:se:oru:diva-41654DOI: 10.3892/ijmm.2014.1623ISI: 000332690600024PubMedID: 24424466Scopus ID: 2-s2.0-84893822678OAI: oai:DiVA.org:oru-41654DiVA, id: diva2:780811
Available from: 2015-01-15 Created: 2015-01-15 Last updated: 2018-09-12Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Elmabsout, Ali AteiaSirsjö, Allan

Search in DiVA

By author/editor
Elmabsout, Ali AteiaSirsjö, Allan
By organisation
School of Health and Medical Sciences, Örebro University, Sweden
In the same journal
International Journal of Molecular Medicine
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 389 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf