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Body mass index, alcohol, tobacco and symptomatic gallstone disease: a Swedish twin study
Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. (CAPS)ORCID iD: 0000-0001-8768-6954
Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2007 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 262, no 5, p. 581-587Article in journal (Refereed) Published
Abstract [en]

Background/Aims: Both genetic and environmental factors are involved in the pathogenesis of gallstone disease (GD). We aimed to examine the association between symptomatic GD and overweight (body mass index, BMI, 25-30 kg m -2), obesity (BMI > 30 kg m-2), alcohol, smoking and smoke-free tobacco by analysing a large twin population.

Methods: The Swedish Twin Registry (STR) was linked to the Swedish Hospital Discharge and Causes of Death Registries for GD and GD-surgery related diagnoses. Weight, height, use of alcohol, smoking and smoke-free tobacco were provided by STR and analysed for possible associations by conditional logistic regression.

Results: Overweight and obesity were associated with a significantly higher risk for symptomatic GD in the whole study population (OR 1.86 and OR 3.38; CI: 1.52-2.28 and 2.28-5.02 respectively). High alcohol consumption was associated with a lower risk for GD in the whole population (OR 0.62; CI: 0.51-0.74) with no difference between discordant monozygotic and dizygotic twins (OR 1.08 and OR 0.96; CI: 0.82-1.42 and 0.79-1.16). Smoking or smoke-free tobacco was not correlated with GD.

Conclusion: Consistent with epidemiological studies, we found positive associations between BMI and the development of symptomatic GD. High alcohol consumption was associated with a decreased risk against GD. Tobacco use has no impact on GD.

Place, publisher, year, edition, pages
2007. Vol. 262, no 5, p. 581-587
Keywords [en]
Alcohol; Body mass index; Conditional logistic regression; Gallstones; Obesity; Overweight; Smoke-free tobacco; Smoking; Swedish Twin Registry; Tobacco
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-40864DOI: 10.1111/j.1365-2796.2007.01860.xISI: 000250266000009PubMedID: 17908165Scopus ID: 2-s2.0-35448959360OAI: oai:DiVA.org:oru-40864DiVA, id: diva2:782606
Available from: 2015-01-21 Created: 2015-01-11 Last updated: 2017-12-05Bibliographically approved

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