oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Cancer Society, Reykjavik, Iceland .
Harvard School of Public Health, Department of Epidemiology, Boston, MA, United States .
Harvard School of Public Health, Department of Epidemiology, Boston, MA, United States; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States .
Department of Biostatistics, Harvard School of Public Health, Boston, MA, United States .
Show others and affiliations
2015 (English)In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 67, no 2, 191-194 p.Article in journal (Refereed) Published
Abstract [en]

Melatonin has anticarcinogenic properties in experimental models. We undertook a case-cohort study of 928 Icelandic men without prostate cancer (PCa) nested within the Age, Gene/Environment Susceptibility (AGES)-Reykjavik cohort to investigate the prospective association between first morning-void urinary 6-sulfatoxymelatonin (aMT6s) levels and the subsequent risk for PCa, under the hypothesis that men with lower aMT6s levels have an increased risk for advanced PCa. We used weighted Cox proportional hazards models to assess the association between first morning-void aMT6s levels and PCa risk, adjusting for potential confounders. A total of 111 men were diagnosed with incident PCa, including 24 with advanced disease. Men who reported sleep problems at baseline had lower morning aMT6s levels compared with those who reported no sleep problems. Men with morning aMT6s levels below the median had a fourfold statistically significant increased risk for advanced disease compared with men with levels above the median (hazard ratio: 4.04; 95% confidence interval, 1.26-12.98). These results require replication in larger prospective studies with longer follow-up.

Patient summary: In this report, we evaluated the prospective association between urinary aMT6s levels and risk of PCa in an Icelandic population. We found that lower levels of aMT6s were associated with an increased risk for advanced PCa.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 67, no 2, 191-194 p.
Keyword [en]
Circadian rhythm, Melatonin levels, Prostate cancer
National Category
Urology and Nephrology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-42358DOI: 10.1016/j.eururo.2014.07.008ISI: 000347033500013PubMedID: 25107635Scopus ID: 2-s2.0-84920699437OAI: oai:DiVA.org:oru-42358DiVA: diva2:785973
Note

Funding Agencies:

RANNIS (the Icelandic Research Fund)

National Institutes of Health (NIH) National Center for Research Resources UL1-RR-025758 KL2-RR-025757

Icelandic Cancer Society

NIH National Cancer Institute R25-CA-098566 T32-CA-09001-35

Prostate Cancer Foundation

NIH National Institutes on Aging (NIA) N01-AG-12100

Icelandic Heart Association

Icelandic Parliament

NIH NIA P01-AG-009975

Available from: 2015-02-04 Created: 2015-02-03 Last updated: 2017-03-22Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Fall, Katja
By organisation
School of Health and Medical Sciences, Örebro University, Sweden
In the same journal
European Urology
Urology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 228 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf