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Gender-specific association of the plasminogen activator inhibitor-1 4G/5G polymorphism with central arterial blood pressure
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska, Institute, Stockholm, Sweden.
epartment of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
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2011 (English)In: American Journal of Hypertension, ISSN 0895-7061, E-ISSN 1941-7225, Vol. 24, no 7, p. 802-8Article in journal (Refereed) Published
Abstract [en]

Background: The functional plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism has previously been associated with hypertension. In recent years, central blood pressure, rather than brachial has been argued a better measure of cardiovascular damage and clinical outcome. The aim of this study was to investigate the possible influence of the 4G/5G polymorphism on central arterial blood pressure in a cohort of elderly individuals.

Methods: We studied 410 individuals, 216 men and 194 women, aged 70-88. Central pressures and pulse waveforms were calculated from the radial artery pressure waveform by the use of the SphygmoCor system and a generalized transfer function. Brachial pressure was recorded using oscillometric technique (Dinamap, Critikon, Tampa, FL). PAI-1 antigen was determined in plasma.

Results: The results showed that central pressures were higher in women carrying the PAI-1 4G/4G genotype compared to female carriers of the 5G/5G genotype, (P = 0.025, P = 0.002, and P = 0.002 for central systolic-, diastolic-, and mean arterial pressure, respectively). The association remained after adjustment for potentially confounding factors related to hypertension. No association of the PAI-1 genotype with blood pressure was found in men. Multiple regression analysis revealed an association between PAI-1 genotype and plasma PAI-1 levels (P = 0.048).

Conclusions: Our findings show a gender-specific association of the PAI-1 4G/5G polymorphism with central arterial blood pressure. The genotype effect was independent of other risk factors related to hypertension, suggesting that impaired fibrinolytic potential may play an important role in the development of central hypertension in women.

Place, publisher, year, edition, pages
New York, USA: Nature Publishing Group, 2011. Vol. 24, no 7, p. 802-8
Keywords [en]
Aorta, arterial stiffness, blood pressure, genetics, hypertension, pressure pulse wave
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-42392DOI: 10.1038/ajh.2011.63ISI: 000291901100014PubMedID: 21490692Scopus ID: 2-s2.0-79959365714OAI: oai:DiVA.org:oru-42392DiVA, id: diva2:786045
Available from: 2015-02-04 Created: 2015-02-04 Last updated: 2018-05-06Bibliographically approved

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Ljungberg, Liza U.

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