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Sialic acid and incidence of hospitalization for diabetes and its complications during 40-years of follow-up in a large cohort: The Värmland survey
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Cardiology and Acute Internal Medicine, Central Hospital, Karlstad, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Endocrine and Diabetes Center, Central Hospital, Karlstad, Sweden.ORCID iD: 0000-0003-1025-1682
Statistical Unit, Värmland County Council, Karlstad, Sweden.
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2014 (English)In: Primary Care Diabetes, ISSN 1751-9918, E-ISSN 1878-0210, Vol. 8, no 4, 352-357 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To examine the association of sialic acid (SA) with first recorded diabetes mellitus-related hospitalization.

Methods: From a population-based study in Varmland, Sweden, between 1962 and 1965, 87,035 men and women were selected and followed for first recorded diabetes-related hospitalization until 2005. The association of SA was calculated and stratified for gender by Cox's proportional hazards models. Adjustments were made for conventional risk factors and socioeconomic status. Association analyses were made for comparisons between SA-levels above and below median.

Results: The mean age was 47.2 (SD 13.0) years and the total numbers of incident diabetes-related hospitalizations in men and women were 3445 and 3273, respectively. Hazard ratios per one standard deviation of SA were 1.12 (95% CI: 1.08-1.17, p < 0.0001) in men and 1.17 (95% CI: 1.13-1.22, p < 0.0001) in women. Interaction analyses indicated a relatively higher SA-associated risk in women than in men with above median SA levels.

Conclusions: In this large population-based cohort followed for more than 40 years, elevated SA, as a marker of systemic inflammation, was independently associated with risk of diabetes and diabetes-related hospitalizations. (C) 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
2014. Vol. 8, no 4, 352-357 p.
Keyword [en]
Epidemiology, Diabetes mellitus, Inflammation, Population, Sialic acid
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-42541DOI: 10.1016/j.pcd.2014.06.002ISI: 000347508500011PubMedID: 24996911Scopus ID: 2-s2.0-84916607502OAI: oai:DiVA.org:oru-42541DiVA: diva2:787086
Note

Funding Agencies:

Värmland County Research Council 10271

Uppsala-Orebro Regional Research Council, Sweden LIVFOU-42841

Available from: 2015-02-09 Created: 2015-02-09 Last updated: 2016-08-10Bibliographically approved

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Citation style
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