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Novel fluorinated surfactants tentatively identified in firefighters using liquid chromatography quadrupole time-of-flight tandem mass spectrometry and a case-control approach
National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Coopers Plains QLD, Australia. (National Research Centre for Environmental Toxicology (Entox))
Örebro University, School of Science and Technology. (MTM)
School of Clinical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane QLD, Australia.
Discipline of General Practice, Royal Brisbane and Women’s Hospital Complex, University of Queensland, Herston QLD, Australia.
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2015 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 49, no 4, p. 2434-2442Article in journal (Refereed) Published
Abstract [en]

Fluorinated surfactant-based aqueous film-forming foams (AFFFs) are made up of per- and polyfluorinated alkyl substances (PFAS) and are used to extinguish fires involving highly flammable liquids. The use of perfluorooctanesulfonic acid (PFOS) and other perfluoroalkyl acids (PFAAs) in some AFFF formulations has been linked to substantial environmental contamination. Recent studies have identified a large number of novel and infrequently reported fluorinated surfactants in different AFFF formulations. In this study, a strategy based on a case-control approach using quadrupole time-of-flight tandem mass spectrometry (QTOF-MS/MS) and advanced statistical methods has been used to extract and identify known and unknown PFAS in human serum associated with AFFF-exposed firefighters. Two target sulfonic acids [PFOS and perfluorohexanesulfonic acid (PFHxS)], three non-target acids [perfluoropentanesulfonic acid (PFPeS), perfluoroheptanesulfonic acid (PFHpS), and perfluorononanesulfonic acid (PFNS)], and four unknown sulfonic acids (Cl-PFOS, ketone-PFOS, ether-PFHxS, and Cl-PFHxS) were exclusively or significantly more frequently detected at higher levels in firefighters compared to controls. The application of this strategy has allowed for identification of previously unreported fluorinated chemicals in a timely and cost-efficient way.

Place, publisher, year, edition, pages
2015. Vol. 49, no 4, p. 2434-2442
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-42555DOI: 10.1021/es503653nISI: 000349806400056PubMedID: 25611076Scopus ID: 2-s2.0-84923090030OAI: oai:DiVA.org:oru-42555DiVA, id: diva2:787286
Note

Funding Agencies:

Queensland Health

Australian Research Council (ARC) FF120100546

ARC DE120100161

Available from: 2015-02-09 Created: 2015-02-09 Last updated: 2018-09-04Bibliographically approved

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Rotander, AnnaKärrman, Anna

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