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Altered tryptophan and alanine transport in cultured fibroblast from boys with attention deficit/hyperactivity disorder (ADHD)
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (Experimentell neuropsykiatri)ORCID iD: 0000-0001-8102-1804
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (Experimentell neuropsykiatri)
Skaraborg Hosp, Dept Pediat, Mariestad, Sweden.
Sahlgrens Acad, Gillberg Neuoropsychiat Ctr, Gothenburg, S.
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2012 (English)In: International Journal of Neuropsychopharmacology, ISSN 1461-1457, E-ISSN 1469-5111, Vol. 15, no s1, 224-224 p.Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Background: The amino acid tyrosine is the precursor for the synthesis of the neurotransmitters dopamine and norepinephrine, while tryptophan is the precursor of serotonin. These neurotransmitters are implicated in the pathophysiology of Attention Deficit/Hyperactivity Disorder (ADHD). A disturbed transport of tyrosine, as well as other amino acids, has been found in a number of other neuropsychiatric disorders, such as schizophrenia, bipolar disorder and autism, when using the fibroblast cell model. Hence, the aim of this study was to explore whether children with ADHD may have disturbed amino acid transport. 

Materials and Methods: Skin biopsies from 14 boys diagnosed with ADHD and from 13 matching boys without a diagnosis of a developmental disorder were obtained, and from the biopsies were primary fibroblast cell lines derived. The transport of the amino acids tyrosine, tryptophan and alanine across the fibroblast cell membranes was measured by the cluster tray method. The kinetic parameters, maximal transport capacity (Vmax) and affinity constant (Km) were determined. Student’s unpaired t-test or the Mann Whitney U test was used to analyze any difference between the two groups.

Results: The tryptophan transport (Vmax) was significantly decreased in the ADHD group in comparison to controls (p=0.039), while the alanine transport (Vmax) was significantly increased in the ADHD group (p=0.031). There was no significant difference regarding the tyrosine transport between the two groups.

Conclusions: A decreased transport capacity of tryptophan implies that less tryptophan is being transported across the BBB in the ADHD group, since tryptophan uses the same transport systems in both fibroblasts and at the blood brain barrier (BBB). This could lead to deficient serotonin access in the brain that might cause disturbances in both the serotonergic and the catecholaminergic neurotransmitter systems, since these systems are highly interconnected. The physiological importance of an elevated transport capacity of alanine to the brain is not known to date.

Place, publisher, year, edition, pages
New York, USA: Cambridge University Press, 2012. Vol. 15, no s1, 224-224 p.
National Category
Medical and Health Sciences Neurology Psychiatry
Research subject
Psychiatry; Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-42595ISI: 000209062500815OAI: oai:DiVA.org:oru-42595DiVA: diva2:787861
Conference
the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012.
Note

Det står E. Elisabeth i publikationenen men det bör stå Elisabeth Fernell som var ifyllt i posten från början så detta har fått stå kvar./vf

Available from: 2015-02-11 Created: 2015-02-11 Last updated: 2017-10-17Bibliographically approved

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