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Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Centre for Rehabilitation Research, Region Örebro County, Örebro, Sweden.ORCID iD: 0000-0002-7468-1633
Department of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK.
Matrix Biology & Tissue Repair Research Unit, College of Biomedical and Life Sciences, School of Dentistry, Cardiff University, Cardiff, UK.
Department of Neurology and Department of Neuroradiology,The Royal Hallamshire Hospital, Sheffield, UK.
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2014 (English)In: Autoimmune Diseases, ISSN 2090-0422, E-ISSN 2090-0430, article id 237107Article in journal (Refereed) Published
Abstract [en]

Objectives: We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease (CD). Antibodies against transglutaminase 6 (anti-TG6) represent a new marker associated with gluten-related neurological dysfunction. The aim of this study was to investigate the prevalence of anti-TG6 antibodies in this group of individuals with an early neurological injury resulting in CP.

Materials and Methods: Sera from 96 patients with CP and 36 controls were analysed for IgA/IgG class anti-TG6 by ELISA.

Results: Anti-TG6 antibodies were found in 12/96 (13%) of patients with CP compared to 2/36 (6%) in controls. The tetraplegic subgroup of CP had a significantly higher prevalence of anti-TG6 antibodies 6/17 (35%) compared to the other subgroups and controls. There was no correlation of anti-TG6 autoantibodies with seropositivity to food proteins including gliadin.

Conclusions: An early brain insult and associated inflammation may predispose to future development of TG6 autoimmunity.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2014. article id 237107
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Pediatrics
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URN: urn:nbn:se:oru:diva-42602DOI: 10.1155/2014/237107PubMedID: 24804082Scopus ID: 2-s2.0-84899518843OAI: oai:DiVA.org:oru-42602DiVA, id: diva2:787972
Available from: 2015-02-12 Created: 2015-02-12 Last updated: 2018-06-15Bibliographically approved

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Stenberg, Reidun

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