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Electroporation therapy for T1 and T2 oral tongue cancer
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
Örebro University Hospital, Örebro, Sweden.
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2011 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 131, no 6, p. 660-664Article in journal (Refereed) Published
Abstract [en]

Conclusion: Electroporation therapy appears to be a safe treatment achieving excellent local tumor control and very good functional results in our study and it should be further clinically evaluated.

Objectives: The objectives of this study were to assess local tumor control, survival, and effects on speech and eating after treatment of tongue cancer with electroporation therapy, a new local therapeutic modality. In this approach intracellular accumulation of a chemotherapeutic agent is achieved by using a locally applied electrical field.

Methods: Fifteen patients with primary T1 and T2 oral tongue cancer were treated with electroporation therapy with intratumorally administered bleomycin. Postoperative radiotherapy was performed when the tumor infiltration was 5 mm or more. The follow-up time was 24 months for the surviving patients and 20.4 months overall. The effects on eating and speech were assessed using the PSS-HN scale and voice recordings.

Results: No local recurrence was recorded in any patient during the follow-up. Three patients died, two from progressive regional disease. Of the 12 surviving patients, 2 patients had regional recurrence and 10 patients including the 5 patients treated with EPT alone were tumor-free both locally and regionally at the last follow-up. The functional outcome for speech and eating were very good.

Place, publisher, year, edition, pages
Informa Healthcare, 2011. Vol. 131, no 6, p. 660-664
Keywords [en]
Electrochemotherapy, bleomycin, local control, survival, speech
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:oru:diva-42889DOI: 10.3109/00016489.2010.541937ISI: 000290571200015PubMedID: 21190422Scopus ID: 2-s2.0-79956051975OAI: oai:DiVA.org:oru-42889DiVA, id: diva2:790199
Note

Funding agency: Örebro County Council; Genetronics Inc.

Available from: 2015-02-23 Created: 2015-02-23 Last updated: 2018-05-07Bibliographically approved
In thesis
1. Curative electrochemotherapy in the head and neck area
Open this publication in new window or tab >>Curative electrochemotherapy in the head and neck area
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. p. 94
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 117
National Category
Surgery
Research subject
Surgery
Identifiers
urn:nbn:se:oru:diva-42215 (URN)978-91-7529-061-4 (ISBN)
Public defence
2015-03-06, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 13:00 (English)
Opponent
Supervisors
Available from: 2015-01-26 Created: 2015-01-26 Last updated: 2017-10-17Bibliographically approved

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Landström, Fredrik J.Löfgren, Lennart A.

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