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Recurrence patterns of squamous cell carcinoma of the penis: Recommendations for follow-up based on a two-centre analysis of 700 patients
The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Örebro University Hospital.
The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Örebro University Hospital.
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2008 (English)In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 54, no 1, 161-169 p.Article in journal (Refereed) Published
Abstract [en]

Background: Current follow-up recommendations for patients with penile carcinoma are based on small numbers of patients.

Objectives: To give further insight into the recurrence patterns of penile carcinoma in different treatment settings and provide recommendations for follow up.

Designs, Setting, and Participants: In this retrospective study, we analysed 700 patients from two referral centres for penile carcinoma for recurrences.

Measurements: Recurrences were categorized as local, regional, or distant. The rate of local recurrences was compared between patients undergoing penile-preserving treatments and partial/total amputation. Regional recurrences were compared between patients surgically staged as pN0 or pN+ and clinically node-negative (cN0) patients subjected to a wait-and-see policy. The total recurrence rate, type of recurrence, time to recurrence, and survival were calculated.

Results and Limitations: 205 out of 700 patients (29.3%) had a recurrence, consisting of 18.6% local, 9.3% regional, and 1.4% distant recurrences. Of the recurrences, 92.2% occurred within 5 yr after primary treatment. All regional and distant recurrences occurred within 50 and 16 mo, respectively. The local recurrence rate was 27.7% after penile-preserving therapy and 5.3% after amputation. The regional recurrence rate was 2.3% in patients staged as pN0, 19.1% in patients staged as pN+, and 9.1% in patients undergoing a wait-and-see policy. The 5-yr disease-specific survival was 92% after a local recurrence and 32.7% after a regional recurrence. All patients with a distant recurrence died within 22 mo. Although the number of analysed patients is substantial, the results do not necessarily reflect those of other centres using different techniques for the management of penile carcinoma.

Conclusions: Patients undergoing penile-preserving therapy, patients surgically staged as pN+, and those undergoing a wait-and-see policy for the nodal status are at high risk of developing a recurrence. Follow-up recommendations are provided based on the risk and impact on survival of a recurrence.

Place, publisher, year, edition, pages
2008. Vol. 54, no 1, 161-169 p.
Keyword [en]
follow-up recommendations, penile neoplasms, recurrence, survival
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-42992DOI: 10.1016/j.eururo.2008.04.016ISI: 000257260400025PubMedID: 18440124Scopus ID: 2-s2.0-44149119291OAI: oai:DiVA.org:oru-42992DiVA: diva2:791246
Available from: 2015-02-27 Created: 2015-02-27 Last updated: 2017-03-27Bibliographically approved
In thesis
1. Penile cancer: studies on prognostic factors
Open this publication in new window or tab >>Penile cancer: studies on prognostic factors
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2014. 77 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 108
Keyword
Human papillomavirus, Incidence, Penile cancer, Prognostic factors, Recurrences, Sentinel node, Survival
National Category
Medical and Health Sciences Surgery
Research subject
Medicine; Surgery
Identifiers
urn:nbn:se:oru:diva-35379 (URN)978-91-7529-002-7 (ISBN)
Public defence
2014-09-26, Universitetssjukhuset, Wilandersalen, Södra Grev Rosengatan, Örebro, 13:00 (English)
Opponent
Supervisors
Available from: 2014-06-17 Created: 2014-06-17 Last updated: 2015-12-28Bibliographically approved

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