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Human Papillomavirus (HPV) and HPV 16-Variant Distribution in Vulvar Squamous Cell Carcinoma in Sweden
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.
Örebro University, School of Medicine, Örebro University, Sweden. Örebro University Hospital.ORCID iD: 0000-0003-2317-5738
Örebro University Hospital.
Umeå University Hospital.
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2012 (English)In: International Journal of Gynecological Cancer, ISSN 1048-891X, E-ISSN 1525-1438, Vol. 22, no 8, 1413-1419 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the human papillomavirus (HPV) and HPV type 16-variant distribution in a series of vulvar squamous cell carcinomas (VSCC) and to evaluate the impact of HPV and HPV 16-variant on prognosis.

Methods: A series of 133 patients who had a diagnosis of VSCC (1983-2008) was selected for the study. Detection of 11 high-risk HPV types (16, 18, 31, 33, 39, 45, 51, 52, 56, 58, and 59) and 2 low-risk HPV types (6 and 11) was performed with real-time polymerase chain reaction. Samples positive for HPV 16 were further analyzed for variant determination of 7 positions in the E6 gene with polymerase chain reaction and pyrosequencing.

Results: Forty (30.8%) of 130 tumors were found to be HPV positive. Human papillomavirus type 16 was found in 31 cases, HPV 18 was found in 2 cases, HPV 33 was found in 5 cases, and HPV 56 and HPV 59 were found in one case each. All but one tumor harboring HPV 16 were of European linage, and the 3 most common variants were E-p (n = 13), E-G350 (n = 7), and E-G131 (n = 5). HPV positivity was associated with the basaloid tumor type and occurred in significantly younger patients. Overall and recurrence-free survival rates were better in HPV-positive cases, but after correction for age and tumor size, HPV status was no longer an independent and significant prognostic factor. The survival rates of the various HPV 16 variants were not significantly different, but there was a trend of worse outcome for the E-G131-variant group.

Conclusions: Human papillomavirus positivity of 30.8% is similar to other reports on VSCC. To our knowledge, this first variant determination of HPV 16 in vulvar carcinoma in a Swedish cohort indicated that the variant E-G131 may have an increased oncogenic potential in patients with VSCC.

Place, publisher, year, edition, pages
2012. Vol. 22, no 8, 1413-1419 p.
Keyword [en]
Vulvar carcinoma, Human papillomavirus, HPV 16 variants
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:oru:diva-43018DOI: 10.1097/IGC.0b013e31826a0471ISI: 000309543700023PubMedID: 23013732Scopus ID: 2-s2.0-84867268780OAI: oai:DiVA.org:oru-43018DiVA: diva2:791378
Available from: 2015-02-27 Created: 2015-02-27 Last updated: 2017-10-18Bibliographically approved
In thesis
1. Characterization of HPV-induced vaginal and vulvar carcinoma
Open this publication in new window or tab >>Characterization of HPV-induced vaginal and vulvar carcinoma
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2014. 83 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 112
Keyword
vaginal carcinoma, vulvar carcinoma, HPV, integration, methylation, genotyping
National Category
Obstetrics, Gynecology and Reproductive Medicine Cancer and Oncology
Research subject
Medicine
Identifiers
urn:nbn:se:oru:diva-38173 (URN)978-91-7529-052-2 (ISBN)
Public defence
2014-12-19, Universitetssjukhuset, Wilandersalen, Södra Grev Rosengatan, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2014-10-27 Created: 2014-10-27 Last updated: 2017-10-17Bibliographically approved

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Lillsunde-Larsson, GabriellaHelenius, GiselaAndersson, SörenElgh, FredrikSorbe, BengtKarlsson, Mats G.
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School of Health and Medical Sciences, Örebro University, SwedenSchool of Medicine, Örebro University, SwedenSchool of Health and Medical Sciences
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International Journal of Gynecological Cancer
Obstetrics, Gynecology and Reproductive Medicine

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CiteExportLink to record
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