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The triangulation of COMT polymorphism rs4680, physical activity, and subjective well-being in retired community-dwelling elderly subjects
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
(English)Manuscript (preprint) (Other academic)
Abstract [en]

Background: During normal aging dopaminergic neuromodulation declines and this has been associated with impaired cognitive function and negative and positive affects. A common polymorphism (rs4680; Val/Met) in the enzyme catechol-O6-methyltransferase (COMT) gene is a determinant of the rate of elimination of dopamine and noradrenaline in the prefrontal cortex, and is therefore thought to modulate dopaminergic signaling.

The aim of the present study was to test whether subjective well-being (SWB) was influenced by interactions between COMT rs4680 genotype, sex, physical activity (PA), and serum biomarkers of somatic health.

Methods: We studied 389 community dwelling, socially active seniors, mean age 74 years and M/F 127/262 (AS cohort). COMT was genotyped by pyrosequencing, PA was assessed by the IPAQ-E, and SWB by the PGWB index.

Results: Male carriers of the rs4680 Met-allele had significantly better SWB than subjects with the ancestral wildtype Val/Val (p=0.009), also when adjusting for age, homocysteine, HbA1c, cystatin C, and IPAQ-E score (p=3.8×10 -5). There was a strong interaction between PA and the rs4680 polymorphism (p=0.001). In women on the other hand the COMT genotype was unrelated to PGWB sum and its subdimensions,

Conclusion: In socially active, elderly retired men, COMT genotype has a major influence on SWB, partly mediated by an interaction with physical activity. This finding should help implementing better public health intervention strategies by tailoring the interventions at appropriately selected subgroups.

National Category
Geriatrics
Identifiers
URN: urn:nbn:se:oru:diva-43289OAI: oai:DiVA.org:oru-43289DiVA, id: diva2:792545
Available from: 2015-03-04 Created: 2015-03-04 Last updated: 2017-10-17Bibliographically approved
In thesis
1. Subjective well-being in old age and its association with biochemical and genetic biomarkers and with physical activity
Open this publication in new window or tab >>Subjective well-being in old age and its association with biochemical and genetic biomarkers and with physical activity
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. p. 48
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 115
Keywords
Subjective well-being, Physical activity, Biomarker, Cystatin C, COMT, Cognition, Old age
National Category
Geriatrics
Research subject
Geriatrics
Identifiers
urn:nbn:se:oru:diva-40408 (URN)978-91-7529-059-1 (ISBN)
Public defence
2015-02-27, Universitetssjukhuset, Bomanssonsalen, Södra Grev Rosengatan, Örebro, 13:00 (Swedish)
Opponent
Supervisors
Available from: 2015-01-08 Created: 2015-01-08 Last updated: 2017-10-17Bibliographically approved

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Olsson, Lovisa A.Nilsson, Torbjörn K

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