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Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts
Department of Anatomy, University of Bern, Bern, Switzerland.
Service de Physiologie Clinique et des Explorations Fonctionnelles Respiratoires et de l'Exercice, Département de Physiologie Équipe d'Accueil 3072, Strasbourg, France.ORCID iD: 0000-0002-8071-4745
Service de Physiologie Clinique et des Explorations Fonctionnelles Respiratoires et de l'Exercice, Département de Physiologie Équipe d'Accueil 3072, Strasbourg, France.
Service de Physiologie Clinique et des Explorations Fonctionnelles Respiratoires et de l'Exercice, Département de Physiologie Équipe d'Accueil 3072, Strasbourg, France.
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2006 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 100, no 4, p. 1258-66Article in journal (Refereed) Published
Abstract [en]

We hypothesized that specific muscular transcript level adaptations participate in the improvement of endurance performances following intermittent hypoxia training in endurance-trained subjects. Fifteen male high-level, long-distance runners integrated a modified living low-training high program comprising two weekly controlled training sessions performed at the second ventilatory threshold for 6 wk into their normal training schedule. The athletes were randomly assigned to either a normoxic (Nor) (inspired O2 fraction = 20.9%, n = 6) or a hypoxic group exercising under normobaric hypoxia (Hyp) (inspired O2 fraction = 14.5%, n = 9). Oxygen uptake and speed at second ventilatory threshold, maximal oxygen uptake (VO2 max), and time to exhaustion (Tlim) at constant load at VO2 max velocity in normoxia and muscular levels of selected mRNAs in biopsies were determined before and after training. VO2 max (+5%) and Tlim (+35%) increased specifically in the Hyp group. At the molecular level, mRNA concentrations of the hypoxia-inducible factor 1alpha (+104%), glucose transporter-4 (+32%), phosphofructokinase (+32%), peroxisome proliferator-activated receptor gamma coactivator 1alpha (+60%), citrate synthase (+28%), cytochrome oxidase 1 (+74%) and 4 (+36%), carbonic anhydrase-3 (+74%), and manganese superoxide dismutase (+44%) were significantly augmented in muscle after exercise training in Hyp only. Significant correlations were noted between muscular mRNA levels of monocarboxylate transporter-1, carbonic anhydrase-3, glucose transporter-4, and Tlim only in the group of athletes who trained in hypoxia (P < 0.05). Accordingly, the addition of short hypoxic stress to the regular endurance training protocol induces transcriptional adaptations in skeletal muscle of athletic subjects. Expressional adaptations involving redox regulation and glucose uptake are being recognized as a potential molecular pathway, resulting in improved endurance performance in hypoxia-trained subjects.

Place, publisher, year, edition, pages
Bethesda, USA: American Physiological Society , 2006. Vol. 100, no 4, p. 1258-66
Keywords [en]
Athletes, messenger ribonucleic acid, redox regulation, glucose uptake
National Category
Medical and Health Sciences Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-43575DOI: 10.1152/japplphysiol.00359.2005ISI: 000236854500025PubMedID: 16540710Scopus ID: 2-s2.0-33646375179OAI: oai:DiVA.org:oru-43575DiVA, id: diva2:794989
Available from: 2015-03-13 Created: 2015-03-13 Last updated: 2017-12-04Bibliographically approved

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Ponsot, Elodie

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