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Genetic and environmental overlap among schizophrenia spectrum endophenotypes and schizophrenia liability during childhood and adolescence
Department of Psychology, University of Southern California, Los Angeles, California, USA.
Department of Psychology, University of Southern California, Los Angeles, California, USA.ORCID iD: 0000-0001-8768-6954
Department of Psychology, University of Southern California, Los Angeles, California, USA.
Departments of Criminology, Psychiatry and Psychology, University of Pennsylvania, USA.
2008 (English)In: Behavior Genetics, ISSN 1573-3297, E-ISSN 1573-3297, Vol. 38, no 6, 625-625 p.Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Objective: In recent years, the p50, p300 amplitude and latency, and Mismatch Negativity (MMN) event related potential components have been proposed as potential endophenoytpes for schizophrenia spectrum disorders on the basis of twin and family studies. To date, there have been no previous studies investigating the genetic overlap between event-related potential indices and schizophenia liability in childhood and adolescence.

Method: P50 sensory gating, p300 amplitude and latency, MMN, and schizotypal traits were measured in a community sample of 605 9–11 year old twin pairs. Structural equation modeling was used to quantify the genetic and environmental contributions to the covariance between schizotypal personality and each of the event-related potential endophenotypes.

Preliminary Results: Moderate phenotypic correlations were found among the measures, ranging between 0.19 and 0.24, considered for psychophysiological data to be quite strong. Subsequent analyses are currently in progress.

Place, publisher, year, edition, pages
2008. Vol. 38, no 6, 625-625 p.
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:oru:diva-43826DOI: 10.1007/s10519-008-9228-xISI: 000260539000057OAI: oai:DiVA.org:oru-43826DiVA: diva2:797594
Conference
38th Annual Meeting of the Behavior-Genetics-Association, Louisville, KY, USA, June 28, 2008
Available from: 2015-03-24 Created: 2015-03-24 Last updated: 2015-04-17Bibliographically approved

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