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Impact of PINCH expression on survival in colorectal cancer patients
University of Skövde, Skövde, Sweden.
Linköping University, Linköping, Sweden.
Linköping University, Linköping, Sweden.
Linköping University, Linköping, Sweden.
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2011 (English)In: BMC Cancer, ISSN 1471-2407, E-ISSN 1471-2407, Vol. 11, article id 103Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The adaptor protein PINCH is overexpressed in the stroma of several types of cancer, and is an independent prognostic marker in colorectal cancer. In this study we further investigate the relationship of PINCH and survival regarding the response to chemotherapy in colorectal cancer.

RESULTS: Paraffin-embedded tissue sections from 251 primary adenocarcinomas, 149 samples of adjacent normal mucosa, 57 samples of distant normal mucosa and 75 lymph node metastases were used for immunohistochemical staining. Stromal staining for PINCH increased from normal mucosa to primary tumour to metastasis. Strong staining in adjacent normal mucosa was related to worse survival independently of sex, age, tumour location, differentiation and stage (p = 0.044, HR, 1.60, 95% CI, 1.01-2.52). PINCH staining at the invasive margin tended to be related to survival (p = 0.051). In poorly differentiated tumours PINCH staining at the invasive margin was related to survival independently of sex, age and stage (p = 0.013, HR, 1.90, 95% CI, 1.14-3.16), while in better differentiated tumours it was not. In patients with weak staining, adjuvant chemotherapy was related to survival (p = 0.010, 0.013 and 0.013 in entire tumour area, invasive margin and inner tumour area, respectively), but not in patients with strong staining. However, in the multivariate analysis no such relationship was seen.

CONCLUSIONS: PINCH staining in normal adjacent mucosa was related to survival. Further, PINCH staining at the tumour invasive margin was related to survival in poorly differentiated tumours but not in better differentiated tumours, indicating that the impact of PINCH on prognosis was dependent on differentiation status.

Place, publisher, year, edition, pages
2011. Vol. 11, article id 103
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-44356DOI: 10.1186/1471-2407-11-103ISI: 000289146300001PubMedID: 21426571Scopus ID: 2-s2.0-79953094759OAI: oai:DiVA.org:oru-44356DiVA, id: diva2:806451
Funder
Swedish Cancer SocietySwedish Research Council
Note

Funding Agency: Health and Research Council in the South-East of Sweden

Available from: 2015-04-20 Created: 2015-04-20 Last updated: 2018-05-07Bibliographically approved
In thesis
1. Molecular studies of radiotherapy and chemotherapy in colorectal cancer
Open this publication in new window or tab >>Molecular studies of radiotherapy and chemotherapy in colorectal cancer
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. p. 73
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 122
Keywords
Colorectal cancer, Radiotherapy, Chemotherapy, p53, p73, PINCH, miRNAs
National Category
Medical Biotechnology
Research subject
Biomedicine
Identifiers
urn:nbn:se:oru:diva-43635 (URN)978-91-7529-070-6 (ISBN)
Public defence
2015-05-29, Prismahuset, Hörsal 2, Örebro universitet, Fakultetsgatan 1, Örebro, 13:00 (Swedish)
Opponent
Supervisors
Funder
Swedish Cancer SocietySwedish Research Council
Note

Funding Agency:

Health Research Council in the South-East of Sweden

Available from: 2015-03-16 Created: 2015-03-16 Last updated: 2017-10-17Bibliographically approved

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