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Significance of an exon 2 G4C14-to-A4T14 polymorphism in the p73 gene on survival in rectal cancer patients with or without preoperative radiotherapy
University of Linköping.
University of Linköping.
Karolinska University Hospital, Stockholm, Sweden.
University of Linköping.
2009 (English)In: Radiotherapy and Oncology, ISSN 0167-8140, E-ISSN 1879-0887, Vol. 92, no 2, 215-20 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: An exon 2 G4C14-->A4T14 polymorphism in the p73 gene was shown to be related to survival in several types of cancers, including colorectal cancer. The purpose was to investigate if this polymorphism was related to survival in rectal cancer patients with or without preoperative radiotherapy.

MATERIALS AND METHODS: DNA extracted from tissue of 138 rectal cancer patients that received preoperative radiotherapy or had surgery alone was typed for the polymorphism by PCR using confronting two-pair primers.

RESULTS: Among patients, 69% had GC/GC genotype, 27% had GC/AT and 4% had AT/AT. In the radiotherapy group, patients carrying the AT (GC/AT+AT/AT) allele had stronger expression of p53 (p=0.001) and survivin protein (p=0.03) than those carrying the GC/GC genotype. Further, among patients receiving preoperative radiotherapy the GC/GC genotype tended to be related to better survival (p=0.20). Patients with GC/GC genotype, along with negative p53 and weak survivin expression showed better survival than the other patients (p=0.03), even after adjusting for TNM stage and tumor differentiation (p=0.01, RR, 7.63, 95% CI, 1.50-38.74). In the non-radiotherapy group, the polymorphism was not related to survival (p=0.74).

CONCLUSIONS: Results suggest that the p73 G4C14-->A4T14 polymorphism could be one factor influencing outcome of preoperative radiotherapy in rectal cancer patients.

Place, publisher, year, edition, pages
2009. Vol. 92, no 2, 215-20 p.
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-44361DOI: 10.1016/j.radonc.2009.06.007PubMedID: 19581013Scopus ID: 2-s2.0-67650992087OAI: oai:DiVA.org:oru-44361DiVA: diva2:806455
Funder
Swedish Cancer Society
Note

Funding Agency: Health Research Council in the South-East of Sweden

Available from: 2015-04-20 Created: 2015-04-20 Last updated: 2017-10-17Bibliographically approved
In thesis
1. Molecular studies of radiotherapy and chemotherapy in colorectal cancer
Open this publication in new window or tab >>Molecular studies of radiotherapy and chemotherapy in colorectal cancer
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. 73 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 122
Keyword
Colorectal cancer, Radiotherapy, Chemotherapy, p53, p73, PINCH, miRNAs
National Category
Medical Biotechnology
Research subject
Biomedicine
Identifiers
urn:nbn:se:oru:diva-43635 (URN)978-91-7529-070-6 (ISBN)
Public defence
2015-05-29, Prismahuset, Hörsal 2, Örebro universitet, Fakultetsgatan 1, Örebro, 13:00 (Swedish)
Opponent
Supervisors
Funder
Swedish Cancer SocietySwedish Research Council
Note

Funding Agency:

Health Research Council in the South-East of Sweden

Available from: 2015-03-16 Created: 2015-03-16 Last updated: 2017-10-17Bibliographically approved

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