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Incidence of HIV and the Prevalence of HIV, Hepatitis B and Syphilis among Youths in Maputo, Mozambique: A Cohort Study
Instituto Nacional de Saúde, Maputo, Mozambique; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique .
Instituto Nacional de Saúde, Maputo, Mozambique; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden; Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique .
Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique; Hospital Central de Maputo, Maputo, Mozambique .
Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique; Hospital Central de Maputo, Maputo, Mozambique .
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2015 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 3, e0121452Article in journal (Refereed) Published
Abstract [en]

Background: Prevalence of HIV in Mozambique among individuals aged 15-49 years is 11.5%. The HIV prevalence is higher in women than in men across the country, peaking at ages 25-29 years and 35-39 years, respectively. In this study, we aimed at determining the prevalence and incidence of HIV, prevalence of Hepatitis B (HBV), and prevalence of syphilis in youths. We also characterized a cohort of youths for future participation in phase I/II HIV vaccine trials.

Methods: The study was conducted at a youth clinic in Maputo Central Hospital from August 2009 to October 2011. Youths of both genders aged 18-24 years (n = 1380) were screened for HIV using a sequential algorithm of two immunochromatographic assays, HBV using an enzyme linked immunosorbant test, and syphilis using a treponemal immunochromatographic strip test. The HIV seronegative participants (n = 1309) were followed-up for 12 months with quarterly study visits. The clinical and behavioral data were collected using structured questionnaires. The HIV seroconversions were confirmed by a molecular assay.

Results: The study population was female dominant (76.8%). All participants had a formal education, with 44.6% studying for technical or higher education degrees. The mean age at sexual debut was 16.6 years (SD: +/-1.74), with 85.6% reporting more than one sexual partner in life. The screening showed the prevalence of HIV, HBV, and syphilis at 5.1% (95% CI: 3.97-6.31), 12.2% (95% CI 10.5%-14.0%), and 0.36% (95% CI 0.15%-0.84%), respectively. The HIV incidence rate was found to be 1.14/100 person years (95% CI: 0.67-1.92). Retention rates were stable throughout the study being 85.1% at the last visit.

Conclusion: Incidence of HIV in this cohort of youths in Maputo was relatively low. Also, the prevalence of HIV and syphilis was lower than the national values in this age group. However, the HBV prevalence was higher than in previous reports in the country.

Place, publisher, year, edition, pages
2015. Vol. 10, no 3, e0121452
National Category
Medical and Health Sciences Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-44543DOI: 10.1371/journal.pone.0121452ISI: 000351987300253PubMedID: 25798607Scopus ID: 2-s2.0-84925705117OAI: oai:DiVA.org:oru-44543DiVA: diva2:810073
Note

Funding Agencies:

Regional HIV/AIDS Team for Africa

Embassy of Sweden, Lusaka - Sweden (Sida) 2150012801

Embassy of Sweden, Lusaka - Norway (Sida) 2150012801

Available from: 2015-05-06 Created: 2015-05-06 Last updated: 2017-03-21Bibliographically approved

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CiteExportLink to record
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