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Prevalence of human T-lymphotropic virus type 1 and 2 infection in Sweden
Örebro University Hospital, Örebro, Sweden.
Linköping University Hospital, Linköping, Sweden.
Maria Beroendecentrum, Centre for Dependency Disorders, Stockholm, Sweden.
Karolinska University Hospital, Solna, Sweden.
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2012 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 44, no 11, 852-9 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Prevalence data on human T-lymphotropic virus types 1 and 2 (HTLV-1/2) in Sweden have not been updated since 1995. The seroprevalence among blood donors at that time was 0.2/10,000. A few years earlier, a high prevalence of HTLV-2 was found in intravenous drug users (IDUs) in Stockholm (3.4%). The objective of this study was to update information on the seroprevalence of HTLV in several study groups.

METHODS: Serum samples from pregnant women, hepatitis C virus (HCV)-positive individuals, and IDUs in Stockholm were investigated for HTLV-1/2 antibodies. Data from the mandatory HTLV-1/2 screening (2003-2006) of in vitro fertilization (IVF) clients were compiled, as well as data from new blood donors.

RESULTS: Eight out of 35,000 IVF patients were positive for anti-HTLV-1/2 (seroprevalence 2.3 per 10,000). Of the anti-HCV-positive individuals (n = 355), 1 sample was HTLV-1-positive (28.2 per 10,000). From 1995 to 2007, 18 HTLV-positive new blood donors were identified out of approximately 550,000 individuals tested (0.3 per 10,000). Thirty-five of 1079 tested IDUs were screening reactive.

CONCLUSIONS: Since the start of screening in 1994, there has been no increased seroprevalence of HTLV-1/2 among blood donors in Sweden. Seroprevalence among Swedish IVF patients is 10 times higher than among blood donors. This finding is comparable to a 2003 European seroprevalence study of pregnant women in 7 countries. However, the possibility that the IVF group includes individuals with a higher risk of acquiring sexually transmitted infections, including HTLV, than the general population cannot be ruled out.

Place, publisher, year, edition, pages
Informa Healthcare, 2012. Vol. 44, no 11, 852-9 p.
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-44556DOI: 10.3109/00365548.2012.689847ISI: 000310008900008PubMedID: 22803699Scopus ID: 2-s2.0-84867752839OAI: oai:DiVA.org:oru-44556DiVA: diva2:810622
Available from: 2015-05-07 Created: 2015-05-07 Last updated: 2017-03-27Bibliographically approved
In thesis
1. Diagnostic strategies for blood borne infections in Sweden
Open this publication in new window or tab >>Diagnostic strategies for blood borne infections in Sweden
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Örebro: Örebro university, 2015. 83 p.
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 124
Keyword
blood borne infections, screening assays, blood donors, HIV, HTVL-1/2, Hepatitis C, Syphilis
National Category
Microbiology in the medical area
Identifiers
urn:nbn:se:oru:diva-44303 (URN)978-91-7529-080-5 (ISBN)
Public defence
2015-05-29, Universitetssjukhuset, hörsal C1, Södra Grev Rosengatan, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2015-04-17 Created: 2015-04-17 Last updated: 2016-11-30Bibliographically approved

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CiteExportLink to record
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Citation style
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