oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Amyotrophic lateral sclerosis in Sweden, 1991-2005
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; Department of Statistics, University of Milano-Bicocca, Milan, Italy.
Department of Neurology, Karolinska Hospital Stockholm.
Show others and affiliations
2009 (English)In: Archives of Neurology, ISSN 0003-9942, E-ISSN 1538-3687, Vol. 66, no 4, p. 515-9Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate the temporal trend of amyotrophic lateral sclerosis (ALS) incidence in Sweden between January 1, 1991, and December 31, 2005, and to explore incidence variations according to major demographic factors.

Design: Population-based study.

Setting: Academic research.

Participants: All incident cases of ALS identified through the Swedish Inpatient Register between January 1, 1991, and December 31, 2005.

Main outcome measure: Age-standardized incidence rates were calculated by applying the observed age-specific incidence rates to the age distribution of the Swedish population in 1991. A linear regression model was used to assess the potential trend of the incidence during calendar years. We also followed up the entire population registered in the 1990 Population and Housing Census for incidence of ALS. Relative risk and 95% confidence interval of ALS associated with demographic variables were estimated using Poisson regression models.

Results: The age-standardized incidence rates increased from 2.32 per 100,000 person-years in 1991-1993 to 2.98 per 100,000 person-years in 2003-2005, representing an annual increase of approximately 2% during the 15 years (P value for trend, .002). The age-specific incidence rates increased in all age groups except those younger than 50 years. The observed increase remained significant when restricting the analysis to individuals born in Sweden (P value for trend, <.001). Compared with individuals born from April through June, those born from October through December were at 11% increased risk of ALS (95% confidence interval, 1.01-1.23).

Conclusions: The incidence of ALS has been increasing during the last 15 years in Sweden. Further studies are warranted to explore the underlying reasons for this observed trend.

Place, publisher, year, edition, pages
Chicago, USA: American Medical Association , 2009. Vol. 66, no 4, p. 515-9
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-41459DOI: 10.1001/archneurol.2009.13ISI: 000265104400014PubMedID: 19364937Scopus ID: 2-s2.0-65249159101OAI: oai:DiVA.org:oru-41459DiVA, id: diva2:811695
Available from: 2015-05-12 Created: 2015-01-14 Last updated: 2017-12-04Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Fall, Katja

Search in DiVA

By author/editor
Fall, Katja
In the same journal
Archives of Neurology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 407 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf