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Biomarkers in volunteers exposed to mobile phone radiation
Centre for Clinical Research, Uppsala University, Västerås Hospital, Västerås, Sweden.
Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden .
Department of Oncology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden .
2015 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 235, no 2, p. 140-146Article in journal (Refereed) Published
Abstract [en]

For some time it has been investigated whether low-intensity non-thermal microwave radiation from mobile phones adversely affects the mammalian blood-brain barrier (BBB). All such studies except one have been either in vitro or experimental animal studies. The one carried out on humans showed a statistically significant increase in serum transthyretin (TTR) 60 min after finishing of a 30-min microwave exposure session. The aim of the present study was to follow up on the finding of the previous one using a better study design. Using biomarkers analyzed in blood serum before and after the exposure this single blinded randomized counterbalanced study, including 24 healthy subjects aged 18-30 years that all underwent three exposure conditions (SAR(10G) = 2 W/kg, SAR(10G) = 0.2 W/kg, sham), tested whether microwaves from an 890-MHz phone-like signal give acute effects on the integrity of brain-shielding barriers. Over time, statistically significant variations were found for two of the three biomarkers (TTR; beta-trace protein); however, no such difference was found between the different exposure conditions nor was there any interaction between exposure condition and time of blood sampling. In conclusion this study failed to show any acute clinically or statistically significant effect of short term microwave exposure on the serum levels of S100 beta, TTR and b-trace protein with a follow up limited to two hours. The study was hampered by the fact that all study persons were regular wireless phone users and thus not naive as to microwave exposure. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
2015. Vol. 235, no 2, p. 140-146
Keywords [en]
Blood-brain barrier; Cordless phones; Non-ionizing radiation; Radiofrequency fields; S100β, β-trace protein; Sleep; Tandomized trial; Transthyretin
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-44635DOI: 10.1016/j.toxlet.2015.03.016ISI: 000353345500009PubMedID: 25839137Scopus ID: 2-s2.0-84926432189OAI: oai:DiVA.org:oru-44635DiVA, id: diva2:812352
Note

Funding Agencies:

Cancer-hjälpen, Orebro University Hospital Cancer Fund, Cancer- och Allergifonden, Sweden

Instituto Nazionale Per L'Assicurazione Contro Gli Infortuni Sul Lavoro (I.N.A.I.L), Italy

Available from: 2015-05-18 Created: 2015-05-18 Last updated: 2017-12-04Bibliographically approved

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Hardell, Lennart

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