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Children with celiac disease are more likely to have attended hospital for prior respiratory syncytial virus infection
Department of Pediatrics, Kalmar County Hospital, Kalmar.
Orebro University Hospital. Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm.ORCID iD: 0000-0003-1024-5602
2014 (English)In: Digestive Diseases and Sciences, ISSN 0163-2116, E-ISSN 1573-2568, Vol. 59, no 7, 1502-1508 p.Article in journal (Refereed) Published
Abstract [en]

Background and Aim: The purpose of this study was to examine the association between celiac disease (CD) and prior respiratory syncytial virus (RSV) infection or any viral bronchiolitis.

Methods: This was a retrospective case–control study. During 2006–2008 small intestinal biopsy data were collected from Sweden’s 28 pathology departments. We identified 3,835 children diagnosed with CD (villous atrophy, Marsh stage 3) before the age of 2 years in 1987 or later. Using conditional logistic regression we calculated odds ratios (ORs) for having a prior diagnosis of respiratory syncytial virus or other viral bronchiolitis compared to 19,102 age- and sex-matched controls.

Results: Of the 3,835 children with CD, 36 (0.9 %) had a prior diagnosis of RSV compared to 117/19,102 (0.6 %) matched controls. This corresponded to an OR of 1.46 (95 % CI 1.03–2.07). ORs were similar in girls and boys. The highest ORs were seen in children developing early CD (before 1 year of age (OR 1.82; 95 % CI 0.91–3.62). Prior record of any type of viral bronchiolitis was found in 3.4 % (132/3,835) of individuals with CD and in 2.0 % (390/19,102) of the matched controls corresponding to an OR of 1.60 (95 % CI 1.33–1.92).

Conclusions: Children with CD diagnosed\2 years of age were more likely to have attended hospital for a prior RSV infection or any viral bronchiolitis than other children.

Place, publisher, year, edition, pages
Dordrecht, Netherlands: Springer, 2014. Vol. 59, no 7, 1502-1508 p.
Keyword [en]
Autoimmunity, bronchiolitis, child, coeliac, infant, inflammation, respiratory syncytial virus
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-44857DOI: 10.1007/s10620-014-3046-1ISI: 000338344500024PubMedID: 24510390Scopus ID: 2-s2.0-84903546143OAI: oai:DiVA.org:oru-44857DiVA: diva2:818437
Funder
Swedish Society of Medicine
Note

Funding Agencies:

Kalmar County Council

Swedish Research Council-Medicine  522-2A09-195

Swedish Celiac Society

Fulbright Commission

Available from: 2015-06-08 Created: 2015-06-08 Last updated: 2017-03-23Bibliographically approved

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