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Differential accumulation and elimination behavior of perfluoroalkyl acid isomers in occupational workers in a manufactory in China
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; Institute of Environment and Health, Ministry of Education, Jianghan University, Wuhan, China.
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2015 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 49, no 11, 6953-6962 p.Article in journal (Refereed) Published
Abstract [en]

In this study, serum and urine samples were collected from 36 occupational workers in a fluorochemical manufacturing plant in China from 2008 to 2012 to evaluate the body burden and possible elimination of linear and branched perfluoroalkyl acids (PFAAs). Indoor dust, total suspended particles (TSP), diet, and drinking water samples were also collected to trace the occupational exposure pathway to PFAA isomers. The geometric mean concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) isomers in the serum were 1386, 371, and 863 ng mL(-1), respectively. The linear isomer of PFOS, PFOA, and PFHxS was the most predominant PFAA in the serum, with mean proportions of 63.3, 91.1, and 92.7% respectively, which were higher than the proportions in urine. The most important exposure routes to PFAA isomers in the occupational workers were considered to be the intake of indoor dust and TSP. A renal clearance estimation indicated that branched PFAA isomers had a higher renal clearance rate than did the corresponding linear isomers. Molecular docking modeling implied that linear PFOS (n-PFOS) had a stronger interaction with human serum albumin (HSA) than branched isomers did, which could decrease the proportion of n-PFOS in the blood of humans via the transport of HSA.

Place, publisher, year, edition, pages
2015. Vol. 49, no 11, 6953-6962 p.
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-45298DOI: 10.1021/acs.est.5b00778ISI: 000355779100070PubMedID: 25927957Scopus ID: 2-s2.0-84930662943OAI: oai:DiVA.org:oru-45298DiVA: diva2:842800
Note

Funding Agencies:

National Basic Research Program of China 2015CB453100

National Natural Science Foundation of China 21477154 21321004

Strategic Priority Research Program of the Chinese Academy of Science XDB14010400 YSW2013A01

RCEES RCEES-QN-20130047F

Available from: 2015-07-22 Created: 2015-07-20 Last updated: 2017-10-17Bibliographically approved

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