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All-cause mortality following a cancer diagnosis amongst multiple sclerosis patients: a Swedish population-based cohort study
Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden; Neuroimmunology Unit, Department of Clinical Neuroscience and Centre for Molecular Medicine, Karolinska Institute and Karolinska University Hospital, Solna, Sweden.
Clinical Epidemiology Unit and Centre for Pharmacoepidemiology, Department of Medicine, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden; Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran .
Department of Neurology, Karolinska University Hospital Huddinge, Stockholm, Sweden; Neuroimmunology Unit, Department of Clinical Neuroscience and Centre for Molecular Medicine, Karolinska Institute and Karolinska University Hospital, Solna, Sweden.
Neuroimmunology Unit, Department of Clinical Neuroscience and Centre for Molecular Medicine, Karolinska Institute and Karolinska University Hospital, Solna, Sweden .
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2015 (English)In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 22, no 7, 1074-1080 p.Article in journal (Refereed) Published
Abstract [en]

Background and purpose: A reduced cancer risk amongst patients with multiple sclerosis (MS) has been reported. Theoretically, this could represent a genuine reduction in risk or, alternatively, diagnostic neglect', where cancer is undiagnosed when symptoms are misattributed to MS.

Objective: Assess all-cause mortality risk following a cancer diagnosis in patients with MS compared with a cohort without MS.

Patients: A cohort of MS patients (n=19364) and a cohort of the general population (n=192519) were extracted from national Swedish registers from 1969 to 2005. All-cause mortality after cancer in MS was compared with the general population. Poisson regression analysis was conducted in the MS and non-MS cohorts separately. The models were adjusted for follow-up duration, year at entry, sex, region and socioeconomic index. The two cohorts were combined and differences in mortality risk were assessed using interaction testing.

Results: The adjusted relative risk (and 95% confidence interval) for all-cause mortality following a cancer diagnosis in MS patients (compared with MS patients without cancer) is 3.06 (2.86-3.27; n=1768) and amongst those without MS 5.73 (5.62-5.85; n=24965). This lower magnitude mortality risk in the MS patients was confirmed by multiplicative interaction testing (P<0.001).

Conclusions: A consistent pattern of lower magnitude of all-cause mortality risk following cancer in MS patients for a range of organ-specific cancer types was found. It suggests that cancer diagnoses tend not to be delayed in MS and diagnostic neglect is unlikely to account for the reduced cancer risk associated with MS. The lower magnitude cancer risk in MS may be due to disease-associated characteristics or exposures.

Place, publisher, year, edition, pages
2015. Vol. 22, no 7, 1074-1080 p.
Keyword [en]
autoimmune, cancer, diagnostic neglect, epidemiology, immune-mediated, mortality, multiple sclerosis, survival, Sweden
National Category
Neurology
Research subject
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-45289DOI: 10.1111/ene.12710ISI: 000356090800010PubMedID: 25903644Scopus ID: 2-s2.0-84930756697OAI: oai:DiVA.org:oru-45289DiVA: diva2:842860
Available from: 2015-07-23 Created: 2015-07-20 Last updated: 2015-07-23Bibliographically approved

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CiteExportLink to record
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