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Proteasome activation: an innovative promising approach for delaying aging and retarding age-related diseases
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
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2015 (English)In: Ageing Research Reviews, ISSN 1568-1637, E-ISSN 1872-9649, Vol. 23, 37-55 p.Article, review/survey (Refereed) Published
Abstract [en]

Aging is a natural process accompanied by a progressive accumulation of damage in all constituent macromolecules (nucleic acids, lipids and proteins). Accumulation of damage in proteins leads to failure of proteostasis (or vice versa) due to increased levels of unfolded, misfolded or aggregated proteins and, in turn, to aging and/or age-related diseases. The major cellular proteolytic machineries, namely the proteasome and the lysosome, have been shown to dysfunction during aging and age-related diseases. Regarding the proteasome, it is well established that it can be activated either through genetic manipulation or through treatment with natural or chemical compounds that eventually result to extension of lifespan or deceleration of the progression of age-related diseases. This review article focuses on proteasome activation studies in several species and cellular models and their effects on aging and longevity. Moreover, it summarizes findings regarding proteasome activation in the major age-related diseases as well as in progeroid syndromes.

Place, publisher, year, edition, pages
2015. Vol. 23, 37-55 p.
Keyword [en]
Ubiquitin-proteasome system, Proteasome activation, Aging, Senescence, Longevity, Age-related diseases
National Category
Geriatrics
Research subject
Geriatrics
Identifiers
URN: urn:nbn:se:oru:diva-45529DOI: 10.1016/j.arr.2014.12.003ISI: 000358094100005PubMedID: 25540941Scopus ID: 2-s2.0-84931570247OAI: oai:DiVA.org:oru-45529DiVA: diva2:845803
Note

Funding Agencies:

Research Funding Program: Thales "GenAge" ThetaALambdaHSigma APi:10479/3.7.12 MIS380228

Research Funding Program: Thales "MAESTRO"

European Union (European Social Fund - ESF)

Greek national funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF), a SYNERGASIA project 11 SigmaYN_1_1112

Greek national funds through the Operational Program "Education and Lifelong Learning" of the National Strategic Reference Framework (NSRF), a KRIPIS project

John S. Latsis Public Benefit Foundation

Empirikion Foundation

Available from: 2015-08-13 Created: 2015-08-12 Last updated: 2015-08-13Bibliographically approved

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Sakellari, Marianthi
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School of Health and Medical Sciences, Örebro University, Sweden
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