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Comparative analysis of stress induced gene expression in caenorhabditis elegans following exposure to environmental and lab reconstituted complex metal mixture
School of Science and Technology, The Life Science Center-Biology, Örebro University, Örebro, Sweden.
School of Science and Technology, The Life Science Center-Biology, Örebro University, Örebro, Sweden.ORCID iD: 0000-0003-3302-7106
Örebro University, School of Science and Technology.
Boliden Mineral AB, Boliden, Sweden.
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2015 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 10, no 7, e0132896Article in journal (Refereed) Published
Abstract [en]

Metals are essential for many physiological processes and are ubiquitously present in the environment. However, high metal concentrations can be harmful to organisms and lead to physiological stress and diseases. The accumulation of transition metals in the environment due to either natural processes or anthropogenic activities such as mining results in the contamination of water and soil environments. The present study used Caenorhabditis elegans to evaluate gene expression as an indicator of physiological response, following exposure to water collected from three different locations downstream of a Swedish mining site and a lab reconstituted metal mixture. Our results indicated that the reconstituted metal mixture exerted a direct stress response in C. elegans whereas the environmental waters elicited either a diminished or abrogated response. This suggests that it is not sufficient to use the biological effects observed from laboratory mixtures to extrapolate the effects observed in complex aquatic environments and apply this to risk assessment and intervention.

Place, publisher, year, edition, pages
2015. Vol. 10, no 7, e0132896
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-45584DOI: 10.1371/journal.pone.0132896ISI: 000358193100095PubMedID: 26168046OAI: oai:DiVA.org:oru-45584DiVA: diva2:846753
Funder
Knowledge Foundation, 20110183
Note

Funding Agencies:

Örebro Universitet J62200

Boliden Mineral AB

Envix Nord AB

ALS Scandinavia AB

Available from: 2015-08-18 Created: 2015-08-18 Last updated: 2017-10-17Bibliographically approved

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CiteExportLink to record
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