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Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Department of Clinical Science, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden; Department of Obstetrics and Gynaecology, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Department of Clinical Chemistry, Örebro University Hospital, Örebro, Sweden.
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2010 (English)In: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 68, no 2, p. 99-113Article in journal (Refereed) Published
Abstract [en]

This review summarizes current knowledge of the effect of folate-mediated one-carbon metabolism and related genetic variants on female fertility and pregnancy viability. Insufficient folate status disrupts DNA methylation and integrity and increases blood homocysteine levels. Elevated levels of follicular fluid homocysteine correlate with oocyte immaturity and poor early embryo quality, while methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with lower ovarian reserves, diminished response to follicular stimulation, and reduced chance of live birth after in vitro fertilization. Embryos carrying multiple MTHFR variants appear to have a selective disadvantage; however, the heterozygousMTHFR 677CT genotype in the mother and fetus provides the greatest chance for a viable pregnancy and live birth, possibly due to a favorable balance in folate cofactor distribution between methyl donor and nucleotide synthesis. The results of previous studies clearly emphasize that imbalances in folate metabolism and related gene variants may impair female fecundity as well as compromise implantation and the chance of a live birth.

Place, publisher, year, edition, pages
2010. Vol. 68, no 2, p. 99-113
Keywords [en]
Fertility; Folate; Homocysteine; MTHFR; Reproduction
National Category
Nutrition and Dietetics Public Health, Global Health, Social Medicine and Epidemiology Medical Genetics
Research subject
Biomedicine; Nutrition
Identifiers
URN: urn:nbn:se:oru:diva-45950DOI: 10.1111/j.1753-4887.2009.00266.xISI: 000273998100003PubMedID: 20137055Scopus ID: 2-s2.0-77950356480OAI: oai:DiVA.org:oru-45950DiVA, id: diva2:857287
Note

Funding Agencies:

Estonian Science Foundation 6498

Estonian Ministry of Education and Science SF0180142 SF0180044s09 PBGMR07903

European Union

Estonian Biocentre and Tartu University

Swedish Institute, and Nyckelfonden

Available from: 2015-09-28 Created: 2015-09-28 Last updated: 2018-09-14Bibliographically approved

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Yngve, Agneta

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