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Genomic diversity of cultivable Lactobacillus populations residing in the neonatal and adult gastrointestinal tract
Teagasc, Moorepark Food Research Centre, Fermoy, Co. Cork, Ireland; Alimentary Pharmabiotic Centre, Cork, Ireland. (Nutrition-Gut-Brain Interactions Research Centre)
Alimentary Pharmabiotic Centre, Cork, Ireland; Department of Microbiology,.
Erinville Hospital and Department of Paediatrics and Child Health, University College, Cork, Ireland.
Erinville Hospital and Department of Paediatrics and Child Health, University College, Cork, Ireland.
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2007 (English)In: FEMS Microbiology Ecology, ISSN 0168-6496, E-ISSN 1574-6941, Vol. 59, no 1, 127-137 p.Article in journal (Refereed) Published
Abstract [en]

The objective of this study was to investigate the cultivable Lactobacillus population in adult and infant faecal material to identify strains shared across a number of individuals. A range of lactobacilli isolated on Lactobacillus-selective agar from faeces of 16 infants and 11 adults were genetically fingerprinted and further characterized by 16S rRNA gene sequencing. The relatedness of all the Lactobacillus strains isolated to known species was also determined both genetically and phenotypically. This study revealed that the human intestine is initially colonized by only a few (1-2) different cultivable strains whereas in adults the pattern becomes more complex with a higher diversity of strains. The adult samples contained three genetically distinct Lactobacillus strains in some cases, while infant samples generally harboured only one dominant Lactobacillus strain. Moreover, the species in general appeared to differ with Lactobacillus rhamnosus and Lactobacillus casei/paracasei found mainly in adults, whereas Lactobacillus gasseri and Lactobacillus salivarius were more commonly isolated in infant samples. The data reaffirm the differences in Lactobacillus populations both between individual subjects and between the infant and adult, with an overall change in the diversity and complexity from early stages of life to adulthood.

Place, publisher, year, edition, pages
Oxon, United Kingdom: Blackwell Publishing, 2007. Vol. 59, no 1, 127-137 p.
Keyword [en]
Cultivable lactobacilli, human gastrointestinal tract, genomic diversity, carbohydrate fermentation
National Category
Medical and Health Sciences Microbiology
Identifiers
URN: urn:nbn:se:oru:diva-46371DOI: 10.1111/j.1574-6941.2006.00202.xISI: 000242784700013PubMedID: 16978242Scopus ID: 2-s2.0-33845634368OAI: oai:DiVA.org:oru-46371DiVA: diva2:866249
Available from: 2015-11-02 Created: 2015-11-02 Last updated: 2017-10-17Bibliographically approved

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