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Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids.
Alimentary Pharmabiotic Centre (APC), County Cork, Ireland . (Nutrition-Gut-Brain Interactions Research Centre)
Alimentary Pharmabiotic Centre (APC), County Cork, Ireland; Teagasc, Moorepark Food Research Centre, Biotechnology Centre, Fermoy, County Cork, Ireland .
University College Cork, National University of Ireland, Ireland.
Alimentary Pharmabiotic Centre (APC), County Cork, Ireland; Teagasc, Moorepark Food Research Centre, Biotechnology Centre, Fermoy, County Cork, Ireland .
2010 (English)In: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 68, no 5, 280-289 p.Article in journal (Refereed) Published
Abstract [en]

Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are precursors of potent lipid mediators, termed eicosanoids, which play an important role in the regulation of inflammation. Eicosanoids derived from n-6 PUFAs (e.g., arachidonic acid) have proinflammatory and immunoactive functions, whereas eicosanoids derived from n-3 PUFAs [e.g., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] have anti-inflammatory properties, traditionally attributed to their ability to inhibit the formation of n-6 PUFA-derived eicosanoids. While the typical Western diet has a much greater ratio of n-6 PUFAs compared with n-3 PUFAs, research has shown that by increasing the ratio of n-3 to n-6 fatty acids in the diet, and consequently favoring the production of EPA in the body, or by increasing the dietary intake of EPA and DHA through consumption of fatty fish or fish-oil supplements, reductions may be achieved in the incidence of many chronic diseases that involve inflammatory processes; most notably, these include cardiovascular diseases, inflammatory bowel disease (IBD), cancer, and rheumatoid arthritis, but psychiatric and neurodegenerative illnesses are other examples.

Place, publisher, year, edition, pages
Malden, USA: Wiley-Blackwell, 2010. Vol. 68, no 5, 280-289 p.
Keyword [en]
Anti-inflammatory, DHA, EPA, fish oil, omega-3
National Category
Medical and Health Sciences Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-46365DOI: 10.1111/j.1753-4887.2010.00287.xISI: 000277168900003PubMedID: 20500789Scopus ID: 2-s2.0-77953904162OAI: oai:DiVA.org:oru-46365DiVA: diva2:866256
Available from: 2015-11-02 Created: 2015-11-02 Last updated: 2015-11-03Bibliographically approved

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