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Parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates
Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto ON, Canada.
Alimentary Pharmabiotic Centre, Cork, Ireland. (Nutrition-Gut-Brain Interactions Research Centre)
Department of Biotechnology, Teagasc Moorepark Food Research Centre, Fermoy, Ireland.
Department of Biotechnology, Teagasc Moorepark Food Research Centre, Fermoy, Ireland.
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2011 (English)In: International Journal of Microbiology, ISSN 1687-918X, E-ISSN 1687-9198, Vol. 2011, article id 130574Article in journal (Refereed) Published
Abstract [en]

We investigated the impact of parenteral antibiotic treatment in the early neonatal period on the evolution of bifidobacteria in the newborn. Nine babies treated with intravenous ampicillin/gentamicin in the first week of life and nine controls (no antibiotic treatment) were studied. Denaturing gradient gel electrophoresis was used to investigate the composition of Bifidobacterium in stool samples taken at four and eight weeks. Bifidobacteria were detected in all control infants at both four and eight weeks, while only six of nine antibiotic-treated infants had detectable bifidobacteria at four weeks and eight of nine at eight weeks. Moreover, stool samples of controls showed greater diversity of Bifidobacterium spp. compared with antibiotic-treated infants. In conclusion, short-term parenteral antibiotic treatment of neonates causes a disturbance in the expected colonization pattern of bifidobacteria in the first months of life. Further studies are required to probiotic determine if supplementation is necessary in this patient group.

Place, publisher, year, edition, pages
New York USA: Hindawi Publishing Corporation, 2011. Vol. 2011, article id 130574
National Category
Medical and Health Sciences Microbiology
Identifiers
URN: urn:nbn:se:oru:diva-46364DOI: 10.1155/2011/130574PubMedID: 20811542Scopus ID: 2-s2.0-80052494524OAI: oai:DiVA.org:oru-46364DiVA, id: diva2:866259
Available from: 2015-11-02 Created: 2015-11-02 Last updated: 2018-05-07Bibliographically approved

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Wall, Rebecca

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CiteExportLink to record
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Citation style
  • apa
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  • vancouver
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  • Other locale
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