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Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota
Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland . (Nutrition-Gut-Brain Interactions Research Centre)
Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland: Department of Microbiology, University College Cork, Cork, Ireland .
Teagasc Moorepark Food Research Centre, Fermoy, Ireland.
Alimentary Pharmabiotic Centre, Biosciences Institute, Cork, Ireland; Teagasc Moorepark Food Research Centre, Fermoy, Ireland .
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2012 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 95, no 5, p. 1278-1287Article in journal (Refereed) Published
Abstract [en]

Background: We previously showed that microbial metabolism in the gut influences the composition of bioactive fatty acids in host adipose tissue.

Objective: This study compared the effect of dietary supplementation for 8 wk with human-derived Bifidobacterium breve strains on fat distribution and composition and the composition of the gut microbiota in mice.

Methods: C57BL/6 mice (n = 8 per group) received B. breve DPC 6330 or B. breve NCIMB 702258 (10(9) microorganisms) daily for 8 wk or no supplement (controls). Tissue fatty acid composition was assessed by gas-liquid chromatography while 16S rRNA pyrosequencing was used to investigate microbiota composition.

Results: Visceral fat mass and brain stearic acid, arachidonic acid, and DHA were higher in mice supplemented with B. breve NCIMB 702258 than in mice in the other 2 groups (P < 0.05). In addition, both B. breve DPC 6330 and B. breve NCIMB 702258 supplementation resulted in higher propionate concentrations in the cecum than did no supplementation (P < 0.05). Compositional sequencing of the gut microbiota showed a tendency for greater proportions of Clostridiaceae (25%, 12%, and 18%; P = 0.08) and lower proportions of Eubacteriaceae (3%, 12%, and 13%; P = 0.06) in mice supplemented with B. breve DPC 6330 than in mice supplemented with B. breve NCIMB 702258 and unsupplemented controls, respectively.

Conclusion: The response of fatty acid metabolism to administration of bifidobacteria is strain-dependent, and strain-strain differences are important factors that influence modulation of the gut microbial community by ingested microorganisms.

Place, publisher, year, edition, pages
Bethesda, USA: American Society for Nutrition , 2012. Vol. 95, no 5, p. 1278-1287
National Category
Medical and Health Sciences Nutrition and Dietetics
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URN: urn:nbn:se:oru:diva-46362DOI: 10.3945/ajcn.111.026435ISI: 000303140700036PubMedID: 22492373Scopus ID: 2-s2.0-84860284262OAI: oai:DiVA.org:oru-46362DiVA, id: diva2:866261
Available from: 2015-11-02 Created: 2015-11-02 Last updated: 2018-09-16Bibliographically approved

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Wall, Rebecca

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