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Consanguineous marriage, prepregnancy maternal characteristics and stillbirth risk: a population-based case-control study
Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden; Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Orebro University Hospital. Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden; Clinical Epidemiology and Biostatistics, Örebro University Hospital, Örebro University, Örebro, Sweden; Research Department of Epidemiology and Public Health, University College London, London, United Kingdom.ORCID iD: 0000-0001-6328-5494
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2015 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 94, no 10, 1095-1101 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: Consanguineous marriage is associated with increased risks for congenital anomalies, low birthweight, and other adverse perinatal outcomes. In this population-based, case-control study we investigated the association between consanguineous marriage (first-cousin marriage) and stillbirth risk, using prospectively collected information from prepregnancy visits.

Material and methods: From 2007 to 2009, we identified 283 stillbirths (cases) and 2088 randomly selected live control births through prepregnancy visits in rural Golestan, Iran. The associations between consanguinity and prepregnancy maternal characteristics and stillbirth risk were examined using multivariate logistic regression.

Results: The rate of consanguineous marriage was 19.4% among cases and 13.6% among controls. Consanguinity was associated with increased stillbirth risk [ odds ratio (OR) 1.53; 95% CI 1.10-2.14]. The association was significantly increased for preterm stillbirth (< 37 gestational weeks) (OR 2.43; 95% CI 1.46-4.04) but not for term stillbirth (>= 37 weeks) (OR 1.14; 95% CI 0.75-1.74). Low and high maternal age, underweight, obesity, nulliparity, a history of infertility or miscarriage, previous obstetric complications (preeclampsia, preterm delivery, and stillbirth in previous pregnancies) were also associated with increased stillbirth risks.

Conclusions: Consanguineous marriage is associated with increased risk of stillbirth, particularly preterm stillbirth. Findings for other maternal risk factors for stillbirth in rural Iran are consistent with previously reported findings from high-income countries.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015. Vol. 94, no 10, 1095-1101 p.
Keyword [en]
Adverse pregnancy outcome, consanguineous marriage, consanguinity, cousin marriage, Golestan province, Iran, maternal characteristics, stillbirth
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Obstetrics and Gynaecology
Identifiers
URN: urn:nbn:se:oru:diva-46397DOI: 10.1111/aogs.12699ISI: 000362511300010PubMedID: 26085011Scopus ID: 2-s2.0-84941744145OAI: oai:DiVA.org:oru-46397DiVA: diva2:866967
Funder
The Karolinska Institutet's Research Foundation
Available from: 2015-11-04 Created: 2015-11-04 Last updated: 2017-03-17Bibliographically approved

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Montgomery, Scott M.
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School of Health and Medical Sciences, Örebro University, SwedenOrebro University Hospital
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CiteExportLink to record
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