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Improved Muscle Mitochondrial Capacity Following Gastric Bypass Surgery in Obese Subjects
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Clinical Medicine. (CVRC)
Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet Solna, Stockholm.
Bariatric Center, Sophiahemmet, Stockholm.
Department of Anaesthesiology and Intensive Care, Karolinska Institutet Huddinge, Stockholm.
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2016 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 26, no 7, 1391-1397 p.Article in journal (Refereed) Published
Abstract [en]

Background: Weight loss resulting from low-calorie diets is often less than expected. We hypothesized that energy restriction would influence proton leakage and improve mitochondrial efficiency, leading to reduced energy expenditure, partly explaining the difficulties in weight loss maintenance.

Methods: Eleven women with a median BMI of 38.5 kg/m(2) (q-range 37-40), and referred to gastric bypass surgery participated. Before surgery, and at 6 months of follow-up, muscle biopsies were collected from the vastus lateralis muscle. Mitochondria were isolated and analyzed for coupled (state 3) and uncoupled (state 4) respiration and mitochondrial capacity (P/O ratio).

Results: At follow-up, the participants had a median BMI of 29.6 kg/m(2) (28.3-32.0). State 3 increased from 20.6 (17.9-28.9) to 34.9 nmol O2/min/U citrate synthase (CS) (27.0-49.0), p = 0.01, while state 4 increased from 2.8 (1.8-4.2) to 4.2 nmol O2/min/U CS (3.1-6.1), although not statistically significant. The P/O ratio increased from 2.7 (2.5-2.8) to 3.2 (3.0-3.4), p = 0.02, indicating improved mitochondrial efficiency.

Conclusions: Six months after gastric bypass surgery, the mitochondrial capacity for coupled, i.e., ATP-generating, respiration increased, and the P/O ratio improved. Uncoupled respiration was not enhanced to the same extent. This could partly explain the decreased basal metabolism and the reduced inclination for weight loss during energy restriction.

Place, publisher, year, edition, pages
New York, USA: Springer, 2016. Vol. 26, no 7, 1391-1397 p.
Keyword [en]
Energy metabolism, Mitochondria, Muscle, Obesity, Thermogenesis, Weight loss
National Category
Nutrition and Dietetics Surgery
Research subject
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-46417DOI: 10.1007/s11695-015-1932-zISI: 000377939200005PubMedID: 26471784Scopus ID: 2-s2.0-84944705891OAI: oai:DiVA.org:oru-46417DiVA: diva2:867200
Funder
Swedish Research Council, 14244
Note

Funding Agencies:

Swedish Transport Administration

Swedish Nutrition Foundation

Stiftelsen Serafimerlasarettet

Stockholm County Council

Karolinska Institutet

Available from: 2015-11-04 Created: 2015-11-04 Last updated: 2017-10-17Bibliographically approved

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