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Electrochemotherapy: Evidence for Cell-type Selectivity In Vitro
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Orebro University Hospital. Department of Otolaryngology.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
Orebro University Hospital. Clinical Research Center.
School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Clinical Research Center, Örebro University Hospital, Örebro, Sweden.
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2015 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 35, no 11, 5813-5820 p.Article in journal (Refereed) Published
Abstract [en]

Aim: Electrochemotherapy (ECT) is a new cancer treatment modality that uses electroporation to potentiate chemotherapeutic agents, especially bleomycin. ECT causes both a direct toxic effect and an anti-vascular effect. The aim of the present study was to investigate a possible selective effect of ECT on the survival of fibroblasts, endothelial cells (HUVEC) and two squamous cell carcinoma cell lines (CAL-27 and SCC-4).

Materials and Methods: Cells were electroporated using two bleomycin concentrations. The survival rate was assessed 1, 2, 3 and 4 days after treatment, by two different assays.

Results: The survival rate of the fibroblasts was statistically significantly higher than the other cell lines at day 4. The HUVEC survival rate was statistically significantly lower than the other cell types at day 1 after electroporation-alone.

Conclusion: A selective survival effect after ECT was observed in vitro, supporting the anti-vascular effect seen in vivo.

Place, publisher, year, edition, pages
International Institute of Anticancer Research, 2015. Vol. 35, no 11, 5813-5820 p.
Keyword [en]
Electrochemotherapy, bleomycin, head and neck cancer, squamous cell carcinoma, fibroblasts, endothelial cells, selectivity
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-46832ISI: 000363794900010PubMedID: 26504002Scopus ID: 2-s2.0-84946055559OAI: oai:DiVA.org:oru-46832DiVA: diva2:874535
Note

Funding Agency:

Örebro County Council

Available from: 2015-11-27 Created: 2015-11-27 Last updated: 2017-03-27Bibliographically approved

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Landström, FredrikIvarsson, Mikaelvon Sydow, Anita Koskelavon Beckerath, MathiasMöller, Claes
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