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Sports genetics: the PPARA gene and athletes’ high ability in endurance sports. A systematic review and meta-analysis
Novartis Pharmaceuticals Corporation, East Hanover NJ, USA.
Örebro University, School of Law, Psychology and Social Work. Department of Psychology, University of Southern California, USA. (CAPS)ORCID iD: 0000-0001-8768-6954
Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
2016 (English)In: Biology of Sport, ISSN 0860-021X, E-ISSN 2083-1862, Vol. 33, no 1, 3-6 p.Article in journal (Refereed) Published
Abstract [en]

A meta-analysis was performed with the aim of re-evaluating the role of the peroxisome proliferator activated receptor alpha (PPARA) gene intron 7 G/C polymorphism (rs4253778) in athletes’ high ability in endurance sports.

Design: A meta-analysis of case control studies assessing the association between the G/C polymorphisms of the PPARA gene and endurance sports was conducted. The Cochrane Review Manager software was used to compare the genotype and allele frequencies between endurance athletes and controls to determine whether a genetic variant is more common in athletes than in the general population. Five studies, encompassing 760 endurance athletes and 1792 controls, fulfilled our inclusion criteria. The pooled odds ratio (and confidence intervals, CIs) for the G allele compared to the C allele was 1.65 (95% CI 1.39-1.96). The pooled OR for the GG genotype compared to the GC genotype was 1.79 (95% CI 1.44-2.22), and for the GG genotype compared to the CC genotype 2.37 (95% CI 1.40-3.99). There was no evidence of heterogeneity (I2 =0%) or of publication bias. Athletes with high ability in endurance sports had a higher frequency of the GG genotype and G allele.

Place, publisher, year, edition, pages
Institute of Sport , 2016. Vol. 33, no 1, 3-6 p.
Keyword [en]
Peroxisome proliferator-activated receptors; Genetic polymorphism; Sports; Meta-analysis
National Category
Sport and Fitness Sciences
Research subject
Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-47070ISI: 000370854600001PubMedID: 26985127OAI: oai:DiVA.org:oru-47070DiVA: diva2:882056
Note

Funding Agencies:

VCTI-UAN

Colciencias

DOI 10.5604/20831862.1180170

Available from: 2015-12-13 Created: 2015-12-13 Last updated: 2017-10-18Bibliographically approved

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CiteExportLink to record
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