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Childhood exposures among mothers and Hodgkin's lymphoma in offspring
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Clinical Epidemiology and Biostatistics; Department of Epidemiology and Public Health, University College London, UK; Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0001-6328-5494
Clinical Epidemiology and Biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Clinical Epidemiology and Biostatistics.ORCID iD: 0000-0002-2088-0530
Clinical Epidemiology and Biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-3552-9153
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2015 (English)In: Cancer Epidemiology, ISSN 1877-7821, E-ISSN 1877-783X, Vol. 39, no 6, 1006-1009 p.Article in journal (Refereed) Published
Abstract [en]

Background: Childhood exposures in mothers, signaled by number of older and younger siblings, have lifelong consequences for aspects of immune function. We hypothesized that these may influence young adult-onset Hodgkin's lymphoma (HL) risk in offspring.

Materials and methods: Swedish registers identified 2028 cases of young adult onset HL (diagnosed between ages 15-39 years) up to 2012 among those born since 1958; and 18,374 matched controls. Conditional logistic regression was used to assess HL risk associated with number of older and younger siblings of mothers.

Results: Having a mother with more than two older siblings is associated with lower HL risk, and the association is statistically significant for mothers with three or more siblings, compared with none. The adjusted odds ratios (and 95% confidence intervals) are 1.04 (0.93-1.16); 0.95 (0.81-1.10); and 0.81 (0.66-0.98) for one, two, and three or more older siblings, respectively. There is no association between number of mothers' younger siblings and HL risk.

Conclusions: Exposures during the childhood of mothers may influence young onset adult HL risk in offspring, perhaps through vertical transmission of infectious agents, or through other long-term influences on maternal immune function.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 39, no 6, 1006-1009 p.
Keyword [en]
Hodgkin’s lymphoma, Case-control, Siblings, Intergenerational relations, Mother
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-47187DOI: 10.1016/j.canep.2015.10.027ISI: 000367444300031PubMedID: 26590334Scopus ID: 2-s2.0-84949771231OAI: oai:DiVA.org:oru-47187DiVA: diva2:888094
Note

Funding Agencies:

UK Economic and Social Research Council (ESRC) ES/JO19119/1

Research Committee at Örebro University Hospital

Örebro University

Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2017-10-18Bibliographically approved

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