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Neurological disease or intellectual disability among sons of female Swedish dental personnel
Karolinska Institutet, Division of Dental Biomaterials and Cariology, Department of Dental Medicine, Stockholm, Sweden.
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Clinical Epidemiology Unit, Karolinska Institutet, Department of Medicine, Stockholm, Sweden; Clinical Epidemiology and Biostatistics, Örebro University Hospital, Örebro, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom.ORCID iD: 0000-0001-6328-5494
Karolinska Institutet, Division of Dental Biomaterials and Cariology, Department of Dental Medicine, Stockholm, Sweden.
Clinical Epidemiology Unit, Karolinska Institutet, Department of Medicine, Stockholm, Sweden.
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2016 (English)In: Journal of Perinatal Medicine, ISSN 0300-5577, E-ISSN 1619-3997, Vol. 44, no 4, 453-460 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Prenatal exposure to elemental mercury may be a potential hazard for the offspring of female dental personnel working with dental amalgam. The aim of this study was to investigate whether potential in utero exposure to mercury might have affected the development of nervous system of the sons of Swedish female dental personnel leading to an increased risk of neurological disease or intellectual disability.

Material and methods: We used national Swedish registers to investigate risks for diseases potentially related to adverse effects on neurodevelopment. Sons of female dentists (n=1690) and dental nurses (n=10,420) were compared with cohorts consisting of sons of other female healthcare personnel. Due to changes in mercury exposure in dentistry during the study period, analyses were stratified by decade of birth. Hazard ratios (HRs) were calculated using Cox proportional hazard models.

Results: We found no elevated risk for neurological disease, epilepsy or intellectual disability among the sons of dental personnel during any of the decades studied. HRs for neurological disease among the dental nurse cohort were even below 1.00 during the 1970s and 1980s. A low number of events resulted in uncertainty regarding results in the dentist cohort.

Conclusions: We did not find any support for the hypothesis that mercury exposure in Swedish dentistry during the 1960s, 1970s or 1980s had any effect on the incidence of neurological disease or intellectual disability among the sons of female dental personnel. Our results imply that current use of dental amalgam should not represent an elevated risk for neurological disease or intellectual disability among the offspring of dental personnel.

Place, publisher, year, edition, pages
Berlin, Germany: Walter de Gruyter, 2016. Vol. 44, no 4, 453-460 p.
Keyword [en]
Dental amalgam, dental nurse, dentist, mercury, neurological disease, occupational exposure
National Category
Environmental Health and Occupational Health Obstetrics, Gynecology and Reproductive Medicine Pediatrics
Research subject
Obstetrics and Gynaecology; Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-47191DOI: 10.1515/jpm-2014-0294ISI: 000375745200015PubMedID: 25741733Scopus ID: 2-s2.0-84969508586OAI: oai:DiVA.org:oru-47191DiVA: diva2:888098
Available from: 2015-12-22 Created: 2015-12-22 Last updated: 2016-06-07Bibliographically approved

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