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Detection of tris-(2,3-dibromopropyl) isocyanurate as a neuronal toxicant in environmental samples using neuronal toxicity-directed analysis
State Key Laboratory of Environmental Chemistry and Ecotoxicology; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
State Key Laboratory of Environmental Chemistry and Ecotoxicology; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
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2011 (English)In: Science China Chemistry, ISSN 1674-7291, Vol. 54, no 10, 1651-1658 p.Article in journal (Refereed) Published
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Abstract [en]

Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region.

Place, publisher, year, edition, pages
Science Press, 2011. Vol. 54, no 10, 1651-1658 p.
Keyword [en]
neuronal toxicity; brominated flame retardant; bioassay directed analysis
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-47550DOI: 10.1007/s11426-011-4371-2ISI: 000296694900016Scopus ID: 2-s2.0-80755128930OAI: oai:DiVA.org:oru-47550DiVA: diva2:895355
Note

Funding Agencies:

National Basic Research Program of China 2009CB421605

National Natural Science Foundation of China  20890111 20921063  20931160427

Ministry of Science and Technology of China  2008IM041300

Available from: 2016-01-18 Created: 2016-01-18 Last updated: 2016-01-21Bibliographically approved

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