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Potential of gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry for screening and quantification of hexabromocyclododecane
Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain.
Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain.
Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain.
Laboratory of Dioxins, IDAEA, CSIC, Barcelona, Spain.
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2016 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 408, no 2, 449-459 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

A fast method for the screening and quantification of hexabromocyclododecane (sum of all isomers) by gas chromatography using a triple quadrupole mass spectrometer with atmospheric pressure chemical ionization (GC-APCI-QqQ) is proposed. This novel procedure makes use of the soft atmospheric pressure chemical ionization source, which results in less fragmentation of the analyte than by conventional electron impact (EI) and chemical ionization (CI) sources, favoring the formation of the [M - Br](+) ion and, thus, enhancing sensitivity and selectivity. Detection was based on the consecutive loses of HBr from the [M - Br](+) ion to form the specific [M - H5Br6](+) and [M - H4Br5](+) ions, which were selected as quantitation (Q) and qualification (q) transitions, respectively. Parameters affecting ionization and MS/MS detection were studied. Method performance was also evaluated; calibration curves were found linear from 1 pg/mu L to 100 pg/mu L for the total HBCD concentration; instrumental detection limit was estimated to be 0.10 pg/mu L; repeatability and reproducibility, expressed as relative standard deviation, were better than 7 % in both cases. The application to different real samples [polyurethane foam disks (PUFs), food, and marine samples] pointed out a rapid way to identify and allow quantification of this compound together with a number of polybrominated diphenyl ethers (BDE congeners 28, 47, 66, 85, 99, 100, 153, 154, 183, 184, 191, 196, 197, and 209) and two other novel brominated flame retardants [i.e., decabromodiphenyl ethane (DBDPE) and 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE)] because of their presence in the same fraction when performing the usual sample treatment.

Place, publisher, year, edition, pages
Heidelberg, Germany: Springer, 2016. Vol. 408, no 2, 449-459 p.
Keyword [en]
Atmospheric pressure chemical ionization, Gas chromatography, Hexabromocyclododecane, Brominated flame retardants, Polyurethane foam (PUF) disks
National Category
Chemical Sciences
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-47979DOI: 10.1007/s00216-015-9146-8ISI: 000368016400011PubMedID: 26554601Scopus ID: 2-s2.0-84954370534OAI: oai:DiVA.org:oru-47979DiVA: diva2:900902
Note

Funding Agencies:

Generalitat Valenciana PROMETEO/2009/054  PROMETEO II 2014/023

Generalitat Valenciana (Collaborative Research on Environment and Food-Safety) ISIC/2012/016

Spanish Ministry of Economy and Competitiveness

FEDER program AGL2012-37201

UNEP

Available from: 2016-02-05 Created: 2016-02-05 Last updated: 2016-02-26Bibliographically approved

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